小鼠对A组链球菌碳水化合物抗体反应的分子剖析
Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.
作者信息
Lutz C T, Bartholow T L, Greenspan N S, Fulton R J, Monafo W J, Perlmutter R M, Huang H V, Davie J M
出版信息
J Exp Med. 1987 Feb 1;165(2):531-45. doi: 10.1084/jem.165.2.531.
Abstract
Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.
摘要
针对A组链球菌碳水化合物（GAC）的单克隆抗体（mAb）由至少两个VH、四个JH、四个Vκ、三个Jκ、一个Vλ和一个Jλ基因片段编码。IdX、IdI-1和Id5独特型决定簇由抗GAC mAb表达，并存在于游离κ链上。这些决定簇的每种模式由一个独特的Vκ基因片段编码，显然不需要特定的Jκ、VH或JH基因片段，也不需要体细胞突变。相比之下，与结合位点相关的独特型决定簇IdI-3a与任何单个V或J基因片段均无关联。
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1
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Mol Immunol. 1982 Dec;19(12):1619-30. doi: 10.1016/0161-5890(82)90273-5.
2
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Hoppe Seylers Z Physiol Chem. 1982 Sep;363(9):1069-76. doi: 10.1515/bchm2.1982.363.2.1069.
3
Clonal nature of the immune response. II. The effect of immunization on clonal commitment.免疫反应的克隆性质。II. 免疫对克隆定向的影响。
J Exp Med. 1980 Jul 1;152(1):151-60. doi: 10.1084/jem.152.1.151.
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