• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.小鼠对A组链球菌碳水化合物抗体反应的分子剖析
J Exp Med. 1987 Feb 1;165(2):531-45. doi: 10.1084/jem.165.2.531.
2
Influence of the immunoglobulin heavy chain locus on expression of the VK1GAC light chain.免疫球蛋白重链基因座对VK1GAC轻链表达的影响。
J Immunol. 1984 Jul;133(1):465-70.
3
Genetics and primary structure of V kappa gene segments encoding antibody to streptococcal group A carbohydrate. Comparison of V kappa gene structure with idiotope expression.编码抗A组链球菌碳水化合物抗体的Vκ基因片段的遗传学与一级结构。Vκ基因结构与独特型表位表达的比较。
J Immunol. 1988 Jan 15;140(2):641-5.
4
Combinational diversity within variable regions bearing the predominant anti-p-azophenylarsonate idiotype of strain A mice.携带A品系小鼠主要抗对偶氮苯胂酸盐独特型的可变区内的组合多样性。
J Immunol. 1985 Apr;134(4):2740-7.
5
Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.利用与异常重链多样性基因（DH）、重链连接基因（JH）和κ轻链可变区（Vκ）片段相关的T15重链可变区（VH），从免疫缺陷的CBA/N小鼠中获得的一种磷酸胆碱结合抗体的氨基酸序列。
J Immunol. 1984 Mar;132(3):1544-9.
6
Monoclonal antibodies to streptococcal group A carbohydrate. I. A dominant idiotypic determinant is located on Vk.抗A群链球菌碳水化合物的单克隆抗体。I. 一个主要的独特型决定簇位于Vk上。
J Immunol. 1982 Oct;129(4):1513-8.
7
Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.针对b型流感嗜血杆菌荚膜多糖的人源抗体的免疫球蛋白轻链可变区基因序列，主要由有限数量的Vκ和Vλ基因片段以及VJ组合所主导。
J Clin Invest. 1992 Mar;89(3):729-38. doi: 10.1172/JCI115649.
8
An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.一种与种系编码的κ轻链可变区相关的独特型标志物，该可变区在疫苗诱导的人类对b型流感嗜血杆菌多糖的抗体反应中占主导地位。
J Clin Invest. 1991 Dec;88(6):1811-8. doi: 10.1172/JCI115502.
9
Interaction of IgG3 anti-streptococcal group A carbohydrate (GAC) antibody with streptococcal group A vaccine: enhancing and inhibiting effects of anti-GAC, anti-isotypic, and anti-idiotypic antibodies.IgG3抗A群链球菌碳水化合物（GAC）抗体与A群链球菌疫苗的相互作用：抗GAC、抗同种型和抗独特型抗体的增强和抑制作用
J Immunol. 1987 Jan 1;138(1):285-92.
10
Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.单个种系VH和Vκ基因编码在用对氨基苯胂酸免疫A系小鼠时引发的主要抗体可变区。
J Exp Med. 1987 Jul 1;166(1):1-11. doi: 10.1084/jem.166.1.1.

引用本文的文献

1
B-1 B Cell-Derived Natural Antibodies against N-Acetyl-d-Glucosamine Suppress Autoimmune Diabetes Pathogenesis.B-1 B 细胞来源的天然抗 N-乙酰-d-氨基葡萄糖抗体抑制自身免疫性糖尿病发病机制。
J Immunol. 2023 Nov 1;211(9):1320-1331. doi: 10.4049/jimmunol.2300264.
2
Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development.新生期接触共生菌来源的抗原指导多糖特异性 B-1 B 细胞库的发育。
Immunity. 2020 Jul 14;53(1):172-186.e6. doi: 10.1016/j.immuni.2020.06.006. Epub 2020 Jun 30.
3
Manipulation of the glycan-specific natural antibody repertoire for immunotherapy.用于免疫治疗的聚糖特异性天然抗体库的操控。
Immunol Rev. 2016 Mar;270(1):32-50. doi: 10.1111/imr.12397.
4
T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin.针对链球菌多糖主要表位N-乙酰葡糖胺的T细胞依赖性抗体反应与心肌肌球蛋白存在交叉反应。
Infect Immun. 2000 Oct;68(10):5803-8. doi: 10.1128/IAI.68.10.5803-5808.2000.
5
Construction of an extended three-dimensional idiotope map by electron microscopic analysis of idiotope-anti-idiotope complexes.通过对独特型-抗独特型复合物进行电子显微镜分析构建扩展的三维独特型图谱。
Proc Natl Acad Sci U S A. 1987 Jul;84(14):4984-8. doi: 10.1073/pnas.84.14.4984.
6
Clonotypic heterogeneity in experimental interstitial nephritis. Restricted specificity of the anti-tubular basement membrane B cell repertoire is associated with a disease-modifying crossreactive idiotype.实验性间质性肾炎中的克隆型异质性。抗肾小管基底膜B细胞库的受限特异性与一种疾病修饰性交叉反应独特型相关。
J Exp Med. 1988 Apr 1;167(4):1296-312. doi: 10.1084/jem.167.4.1296.
7
Syrinx 2A: an improved lambda phage vector designed for screening DNA libraries by recombination in vivo.Syrinx 2A：一种经过改进的λ噬菌体载体，设计用于通过体内重组筛选DNA文库。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4379-83. doi: 10.1073/pnas.84.13.4379.
8
The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies.小鼠对新型隐球菌感染的抗体反应：多糖结合抗体中VH和VL的使用情况
J Exp Med. 1991 Jul 1;174(1):151-60. doi: 10.1084/jem.174.1.151.

本文引用的文献

1
Classification of mouse VK groups based on the partial amino acid sequence to the first invariant tryptophan: impact of 14 new sequences from IgG myeloma proteins.基于至首个不变色氨酸的部分氨基酸序列对小鼠VK基因群的分类：来自IgG骨髓瘤蛋白的14条新序列的影响
Mol Immunol. 1982 Dec;19(12):1619-30. doi: 10.1016/0161-5890(82)90273-5.
2
Murine VK25 isotype sequence: monoclonal antibody 2S1.3 specific for the group A streptococcal polysaccharide.小鼠VK25同种型序列：对A组链球菌多糖具有特异性的单克隆抗体2S1.3。
Hoppe Seylers Z Physiol Chem. 1982 Sep;363(9):1069-76. doi: 10.1515/bchm2.1982.363.2.1069.
3
Clonal nature of the immune response. II. The effect of immunization on clonal commitment.免疫反应的克隆性质。II. 免疫对克隆定向的影响。
J Exp Med. 1980 Jul 1;152(1):151-60. doi: 10.1084/jem.152.1.151.
4
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.信使核糖核酸序列定义了对2-苯基恶唑酮异常受限的免疫球蛋白G反应及其早期多样化。
Nature. 1983;304(5924):320-4. doi: 10.1038/304320a0.
5
kappa-Chain restriction in anti-galactan antibodies.抗半乳聚糖抗体中的κ链限制
J Immunol. 1982 Aug;129(2):615-8.
6
VH families in the antibody response to p-azophenylarsonate: correlation between serology and amino acid sequence.对对氨基苯砷酸抗体应答中的VH家族：血清学与氨基酸序列之间的相关性
J Immunol. 1982 Jul;129(1):193-9.
7
Structural diversity among anti-p-azophenylarsonate monoclonal antibodies from A/J mice; comparison of Id- and Id+ sequences.来自A/J小鼠的抗对偶氮苯胂酸盐单克隆抗体的结构多样性；独特型和独特型阳性序列的比较。
Mol Immunol. 1981 Dec;18(12):1065-77. doi: 10.1016/0161-5890(81)90022-5.
8
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.免疫球蛋白重链多样性DNA片段的组织、结构与组装
J Exp Med. 1982 Jan 1;155(1):201-18. doi: 10.1084/jem.155.1.201.
9
A simple method for estimating the probable numbers of different antibodies by examining the repeat frequencies of sequences or isoelectric focusing patterns.一种通过检查序列重复频率或等电聚焦模式来估计不同抗体可能数量的简单方法。
Mol Immunol. 1981 Jan;18(1):29-38. doi: 10.1016/0161-5890(81)90045-6.
10
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.免疫球蛋白重链连接区基因序列及其在抗体多样性产生中的作用。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):509-13. doi: 10.1073/pnas.78.1.509.

小鼠对A组链球菌碳水化合物抗体反应的分子剖析

Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.

作者信息

Lutz C T, Bartholow T L, Greenspan N S, Fulton R J, Monafo W J, Perlmutter R M, Huang H V, Davie J M

出版信息

J Exp Med. 1987 Feb 1;165(2):531-45. doi: 10.1084/jem.165.2.531.

DOI:10.1084/jem.165.2.531
PMID:3102673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188515/
Abstract

Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.

摘要

针对A组链球菌碳水化合物（GAC）的单克隆抗体（mAb）由至少两个VH、四个JH、四个Vκ、三个Jκ、一个Vλ和一个Jλ基因片段编码。IdX、IdI-1和Id5独特型决定簇由抗GAC mAb表达，并存在于游离κ链上。这些决定簇的每种模式由一个独特的Vκ基因片段编码，显然不需要特定的Jκ、VH或JH基因片段，也不需要体细胞突变。相比之下，与结合位点相关的独特型决定簇IdI-3a与任何单个V或J基因片段均无关联。