Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Exeter EX4 4PY, UK.
Int J Mol Sci. 2019 Apr 26;20(9):2067. doi: 10.3390/ijms20092067.
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; and .
前体 mRNA 的选择性剪接允许从给定基因产生多个剪接异构体，它们可以具有不同的功能。事实上，剪接异构体可以具有相反的功能，有许多情况下，剪接异构体作为典型异构体功能的抑制剂，从而为重要过程增加了额外的调控层。血管生成是一个重要的过程，受到选择性剪接机制的调控。本综述重点介绍了参与血管生成过程的关键基因的选择性剪接异构体；和。
