厄贝沙坦对 2 型糖尿病大鼠心肌纤维化模型 AGEs-RAGE 和 MMPs 系统的影响。
Effect of Irbesartan on AGEs-RAGE and MMPs systems in rat type 2 diabetes myocardial-fibrosis model.
机构信息
1 Department of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, China.
2 Science Research Centre, Bengbu Medical College, Bengbu, Anhui 233030, China.
出版信息
Exp Biol Med (Maywood). 2019 May;244(7):612-620. doi: 10.1177/1535370219840981. Epub 2019 Apr 26.
Abstract
There are about 425 million diabetes patients (20-79 years) in the world according to the International Diabetes Federation Diabetes Atlas - 8th Edition. The cardiovascular complication is one of the major causes of death in diabetes patients. Myocardial fibrosis is one of the serious pathological changes, so investigating the pathogenesis of myocardial fibrosis has the significant value. Our study aims to investigate the effect of Irbesartan (the angiotensin II receptor antagonist) on the changes of AGE-RAGE system and MMP family components, and analyzes the potential mechanisms in type 2 diabetes-induced myocardial fibrosis. Our results provide the theoretical base for better understanding the pathogenesis in type 2 diabetes-induced myocardial complication. It is useful for clinicians to select the effective therapeutic measures for treatment of type 2 diabetes-induced organ fibrosis.
摘要
根据国际糖尿病联合会第 8 版糖尿病地图集，全球约有 4.25 亿糖尿病患者（20-79 岁）。心血管并发症是糖尿病患者死亡的主要原因之一。心肌纤维化是一种严重的病理变化，因此研究心肌纤维化的发病机制具有重要意义。我们的研究旨在探讨厄贝沙坦（血管紧张素 II 受体拮抗剂）对 AGE-RAGE 系统和 MMP 家族成分变化的影响，并分析其在 2 型糖尿病诱导心肌纤维化中的潜在机制。我们的研究结果为更好地理解 2 型糖尿病诱导的心肌并发症发病机制提供了理论依据。这对于临床医生选择有效的治疗措施来治疗 2 型糖尿病诱导的器官纤维化是有用的。
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