Popp M B, Brennan M F, Morrison S D
JPEN J Parenter Enteral Nutr. 1987 Jan-Feb;11(1):14-7. doi: 10.1177/014860718701100114.
Rats with intravascular catheters connected to infusion systems are frequently used in the investigation of nutritional and metabolic problems. Although the animal is often referred to as "unrestrained," there is no information on the effect of the catheter assembly or total parenteral nutrition (TPN) on total (TEE), activity (AEE), and resting (REE) energy expenditure (TEE = REE + AEE). Male Fischer 344 rats were studied in an analytical respiration calorimeter. Normal unoperated rats, aseptically catheterized orally fed rats from postoperative day 1 to 7, and TPN rats were studied. Orally fed catheterized rats had weight loss, negative nitrogen balance, negative energy balance, elevated REE, and normal AEE during the first 4 postoperative days. Their weight gain, positive nitrogen balance, AEE, and REE were almost identical to those of normal rats over postoperative days 5 through 7. REE and AEE in TPN rats were similar to values in normal rats. These data indicate that catheter operation and TPN cause no abnormality in AEE and REE if adequate time is allowed for recovery from catheter operation and strict attention is given to asepsis.
连接输液系统的血管内导管大鼠常用于营养和代谢问题的研究。尽管这种动物常被称为“不受限制”，但关于导管组件或全胃肠外营养（TPN）对总能量消耗（TEE）、活动能量消耗（AEE）和静息能量消耗（REE）（TEE = REE + AEE）的影响尚无相关信息。在分析呼吸热量计中对雄性Fischer 344大鼠进行了研究。研究对象包括正常未手术大鼠、术后第1天至第7天经口喂养的无菌插管大鼠以及TPN大鼠。经口喂养的插管大鼠在术后前4天体重减轻、氮平衡为负、能量平衡为负、REE升高且AEE正常。在术后第5天至第7天，它们的体重增加、氮平衡为正、AEE和REE与正常大鼠几乎相同。TPN大鼠的REE和AEE与正常大鼠的值相似。这些数据表明，如果给予足够的时间从导管操作中恢复并严格注意无菌操作，导管操作和TPN不会导致AEE和REE出现异常。
