Ebbert M L, Farraj M, Hwang L T
JPEN J Parenter Enteral Nutr. 1987 Jan-Feb;11(1):42-5. doi: 10.1177/014860718701100142.
So that the actual contamination rate of intravenous fat emulsions, as well as the type of microbial contamination, could be quantified, 103 bottles of 10% fat emulsion were collected near infusion completion from patients' bedsides. All samples were cultured and compared according to actual hanging time, in addition to the amount and type of microbial contamination. Recovered organisms included Escherichia coli, Staphylococcus epidermidis, diphtheroids, and Micrococcus. Sample analysis failed to demonstrate significant differences in extrinsic microbial contamination rate or organism multiplication between samples infusing for less than or equal to 12 hr and those infusing longer. Although these products support microbial growth, the contaminants introduced into the infusate by environmental or touch contamination yielded minimal colony growth. No patient developed signs or symptoms of bacteremia during the study period. Therefore, infusion of intravenous fat emulsion products over extended periods of time in this study did not increase the risk of developing infectious complications.
为了量化静脉脂肪乳剂的实际污染率以及微生物污染类型，在输液即将结束时从患者床边收集了103瓶10%的脂肪乳剂。除了微生物污染的数量和类型外，所有样本均根据实际悬挂时间进行培养和比较。回收的微生物包括大肠杆菌、表皮葡萄球菌、类白喉杆菌和微球菌。样本分析未能显示输注时间小于或等于12小时的样本与输注时间更长的样本在外源性微生物污染率或微生物繁殖方面存在显著差异。尽管这些产品支持微生物生长，但环境或接触污染引入输注液中的污染物产生的菌落生长极少。在研究期间，没有患者出现菌血症的体征或症状。因此，在本研究中长时间输注静脉脂肪乳剂产品并未增加发生感染性并发症的风险。
