[具体基因名称]多态性对子宫内膜癌风险及发病的影响。 需注意，你提供的原文中“and”前面缺少具体内容，这里是按补充完整后进行的翻译，你可根据实际情况修改。
Impact of and Polymorphisms on Endometrial Cancer Risk and Onset.
作者信息
Wujcicka Wioletta, Zając Agnieszka, Stachowiak Grzegorz
机构信息
Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
Department of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital - Research Institute, Medical University of Lodz, Lodz, Poland.
出版信息
In Vivo. 2019 May-Jun;33(3):917-924. doi: 10.21873/invivo.11559.
BACKGROUND/AIM: The aim of this study was to determine the joint effect of single nucleotide polymorphisms (SNPs) of MDM2, TP53, and CDKN2A (P14ARF) genes on the onset and course of endometrial cancer (EC) in postmenopausal women.
MATERIALS AND METHODS
The study group consisted of 144 EC women and 50 non-cancer controls. MDM2 rs22279744, TP53 rs1042522, and P14ARF rs3088440, rs3731217, and rs3731245 SNPs were analysed.
RESULTS
The double-SNP combinations T-C, T-T, or T-G in MDM2 SNP 309 and P14ARF polymorphisms decreased EC risk. The triple-SNP combinations T-C-T, T-C-G, or T-T-G in MDM2 SNP and two P14ARF polymorphisms decreased EC risk. The multiple-SNP combination T-C-T-G in MDM2 and three P14ARF polymorphisms decreased EC risk. The G-Arg-C-T-G carriers were at increased EC risk, while the T-Arg-C-T-G carriers were at decreased EC risk.
CONCLUSION
MDM2 SNP309 plays a role in EC onset in postmenopausal women.
背景/目的：本研究旨在确定MDM2、TP53和CDKN2A（P14ARF）基因的单核苷酸多态性（SNP）对绝经后妇女子宫内膜癌（EC）发病及病程的联合影响。
材料与方法
研究组由144例EC患者和50例非癌对照组成。分析了MDM2 rs22279744、TP53 rs1042522以及P14ARF rs3088440、rs3731217和rs3731245单核苷酸多态性。
结果
MDM2 SNP 309与P14ARF多态性中的双SNP组合T-C、T-T或T-G降低了EC风险。MDM2 SNP与两个P14ARF多态性中的三SNP组合T-C-T、T-C-G或T-T-G降低了EC风险。MDM2与三个P14ARF多态性中的多SNP组合T-C-T-G降低了EC风险。G-Arg-C-T-G携带者的EC风险增加，而T-Arg-C-T-G携带者的EC风险降低。
结论
MDM2 SNP309在绝经后妇女子宫内膜癌发病中起作用。
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