托珠单抗治疗难治性大动脉炎合并主动脉瘤
[Tocilizumab for refractory Takayasu arteritis with aortic aneurysm].
作者信息
Frikha F, Garbaa S, Bouattour Y, Snoussi M, Loukil H, Ben Salah R, Bahloul Z
机构信息
Service de médecine interne, CHU Hédi Chaker, 3029 Sfax, Tunisie.
Service de médecine interne, CHU Hédi Chaker, 3029 Sfax, Tunisie.
出版信息
J Med Vasc. 2019 May;44(3):237-239. doi: 10.1016/j.jdmv.2019.02.004. Epub 2019 Mar 13.
Takayasu arteritis (TA) is a form of large vessel vasculitis (LVV) which affects the aorta and the main arteries. Many reports showed efficacy of biologic drugs (TNF α inhibitors and interleukin 6 inhibitors) in refractory TA cases. We report the case of a 46-year-old woman with refractory TA complicated by giant aortic aneurysm (AA) and severe hypertension, treated efficacy with tocilizumab (anti-interleukin 6 receptor monoclonal antibody).
大动脉炎（TA）是一种累及主动脉和主要动脉的大血管血管炎（LVV）。许多报告显示生物药物（肿瘤坏死因子α抑制剂和白细胞介素6抑制剂）对难治性TA病例有效。我们报告了一例46岁患有难治性TA并伴有巨大主动脉瘤（AA）和严重高血压的女性病例，使用托珠单抗（抗白细胞介素6受体单克隆抗体）治疗的疗效。
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