Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, China.
Medical College, Qingdao University, Qingdao 266071, China.
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:380-386. doi: 10.1016/j.msec.2019.03.075. Epub 2019 Mar 23.
An auxiliary electrode electrospinning method is proposed to deposit N-octyl-2-cyanoacrylate (NOCA) medical glue fibrous membrane on kidney for in-situ fast hemostasis. A metal electrode equipped to the spinning needle is used to confine the divergence angle of jet. Compared to the conventional electrospinning method, the fiber deposition area has reduced by 2.5 times, and it can achieve in-situ accurate deposition. Moreover, it reduces both the external dimension and over-reliance on electricity, which is superior to previous air-flow assisted electrospinning method. In addition, in situ accurate deposition of NOCA on the kidney exhibits fast hemostasis within 10 s, confirming that this auxiliary electrode method can be applied in outdoors for fast hemostasis. Further pathological studies indicate that this auxiliary electrode method can reduce the inflammatory response of tissues due to the better accurate deposition. This portable hand-held device with the auxiliary electrode method may have potential application in fast hemostasis for outdoors due to its accurate deposition and portability characteristics.
提出了一种辅助电极静电纺丝方法，用于将 N-辛基-2-氰基丙烯酸酯（NOCA）医用胶纤维膜沉积在肾脏上以实现原位快速止血。将金属电极安装到纺丝针上，以限制射流的发散角度。与传统的静电纺丝方法相比，纤维沉积面积减少了 2.5 倍，可以实现原位精确沉积。此外，它还减少了对外形尺寸和对电力的过度依赖，优于以前的气流辅助静电纺丝方法。此外，NOCA 在肾脏上的原位精确沉积可在 10s 内实现快速止血，证实了这种辅助电极方法可以在户外快速止血。进一步的病理研究表明，由于更好的精确沉积，这种辅助电极方法可以减少组织的炎症反应。由于其精确沉积和便携性的特点，这种带有辅助电极的便携式手持设备可能具有在户外快速止血的潜在应用。
