Department of Interventional Radiology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China.
Department of Interventional Radiology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China.
J Vasc Interv Radiol. 2019 May;30(5):661-667. doi: 10.1016/j.jvir.2019.02.008.
To evaluate the efficacy and safety of prostatic artery embolization (PAE) performed to treat gross hematuria secondary to benign prostatic hyperplasia (BPH).
Between February 2014 and December 2017, 20 patients with gross hematuria secondary to BPH refractory to medical treatment underwent PAE in our institution. Technical success was defined as bilateral PAE. International Prostate Symptom Score (IPSS), quality of life (QoL), and clinical review were assessed before PAE and at 3 and 12 months after procedure. Short- and medium-term clinical successes were defined as resolution of gross hematuria with no recurrence at 3 and 12 months, respectively.
Technical success rate was 100%. No major adverse events were recorded. Minor complications included gluteal pain, nausea, and fever in 7 patients. At 3 months, there were improvements in IPSS (21.1 ± 6.6 to 9.8 ± 4.7, P < .001) and QoL (5.1 ± 1.7 to 2.4 ± 1.3, P < .001). At 12 months, there were improvements in IPSS (8.1 ± 2.5, P < .001) and QoL (2.1 ± 1.0, P < .001). At 3 months, recurrent hematuria was reported in 3 of 20 patients (85% short-term clinical success rate). One of the remaining 17 patients had developed recurrent hematuria by 12 months (80% medium-term clinical success rate).
PAE is a safe and effective means of treating gross hematuria caused by BPH refractory to medical treatment. PAE offers a reasonable option for such patients who are not suitable for surgical therapy.
评估前列腺动脉栓塞术（PAE）治疗因前列腺增生（BPH）导致的肉眼血尿的疗效和安全性。
在 2014 年 2 月至 2017 年 12 月期间，我们机构对 20 例因 BPH 导致的药物治疗无效的肉眼血尿患者进行了 PAE。技术成功定义为双侧 PAE。在 PAE 前、术后 3 个月和 12 个月，评估国际前列腺症状评分（IPSS）、生活质量（QoL）和临床评估。短期和中期临床成功定义为术后 3 个月和 12 个月肉眼血尿完全缓解且无复发。
技术成功率为 100%。未记录到主要不良事件。少数并发症包括 7 例患者出现臀痛、恶心和发热。术后 3 个月，IPSS（21.1±6.6 降至 9.8±4.7，P<0.001）和 QoL（5.1±1.7 降至 2.4±1.3，P<0.001）均有改善。术后 12 个月，IPSS（8.1±2.5，P<0.001）和 QoL（2.1±1.0，P<0.001）均有改善。术后 3 个月，20 例患者中有 3 例（85%短期临床成功率）报告血尿复发。其余 17 例患者中有 1 例在 12 个月时出现血尿复发（80%中期临床成功率）。
PAE 是治疗药物治疗无效的 BPH 引起的肉眼血尿的一种安全有效的方法。对于不适合手术治疗的此类患者，PAE 是一种合理的选择。
