Aguilar G L, Blumenkrantz M S, Egbert P R, McCulley J P
Arch Ophthalmol. 1979 Jan;97(1):96-100. doi: 10.1001/archopht.1979.01020010036008.
Patients with endogenous Candida endophthalmitis associated with intravenous (IV) drug abuse may manifest ocular and systemic signs different from those seen in other forms of endogenous Candida endophthalmitis. There may be a sparcity of evidence of systemic candidiasis, including negative serology and normal physical examination results. Anterior uveitis and extensive vitreous involvement are common and do not necessarily have associated typical retinal lesions, which are more commonly seen in the compromised host. This may occur either because of the more transitory nature of choroidal or retinal lesions or because these patients often seek treatment at later stages. Even with a typical clinical picture, it is difficult to get culture confirmation of the diagnosis. Material obtained by vitrectomy must be concentrated before inoculation of media because of the known difficulty of culturing Candida from the vitreous cavity.
与静脉注射毒品相关的内源性念珠菌性眼内炎患者可能表现出与其他形式的内源性念珠菌性眼内炎不同的眼部和全身症状。可能缺乏系统性念珠菌病的证据，包括血清学阴性和体格检查结果正常。前葡萄膜炎和广泛的玻璃体受累很常见，且不一定伴有典型的视网膜病变，而在免疫功能低下的宿主中更常见到这些病变。这可能是由于脉络膜或视网膜病变的性质更为短暂，或者是因为这些患者往往在疾病后期才寻求治疗。即使临床表现典型，也难以通过培养确诊。由于已知从玻璃体腔培养念珠菌困难，因此玻璃体切除获得的材料在接种培养基前必须进行浓缩。
