Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
J Neurol Sci. 2019 Jun 15;401:67-71. doi: 10.1016/j.jns.2019.04.012. Epub 2019 Apr 11.
This study aimed to explore clinical correlates of repetitive speech disorders in patients with Parkinson's disease (PD).
This study investigated speech function (Assessment of Motor Speech for Dysarthria and Stuttering Severity Instrument-3), motor function (Unified Parkinson's Disease Rating Scale III [UPDRS-III] and UPDRS-IV), cognitive function (Mini-Mental State Examination [MMSE], Montreal Cognitive Assessment [MoCA], Stroop color-word test, verbal fluency, digit span tests, and line orientation), and activities of daily living of 113 PD patients. Comparison between groups (independent t-tests, Mann-Whitney U tests, or χ test) and linear regression analyses were performed to determine clinical correlates of repetitive speech disorders.
Totally, 65 patients (57.5%) had repetitive speech disorders. Patients with repetitive speech disorders had significantly worse UPDRS-III (P = .049), MoCA (P = .030), and speech function and higher levodopa equivalent daily dose (LEDD; P = .031) than those without repetitive speech disorders. Males were significantly predominant in patients with repetitive speech disorders (64.6%) compared to those without repetitive speech disorders (18.7%; P < .001). The univariate and subsequent multiple linear regression analyses revealed that the severity of repetitive speech disorders significantly correlated with gender (P < .001), MoCA (P = .006), and speech variables (abnormal rate, P = .007; imprecise consonants, P = .043), independent from disease duration, UPDRS III, and LEDD.
PD patients with repetitive speech disorders had worse motor, cognitive, and speech functions than those without repetitive speech disorders. The most influential factor for repetitive speech disorders might be male gender.
本研究旨在探讨帕金森病（PD）患者重复言语障碍的临床相关性。
本研究调查了 113 名 PD 患者的言语功能（构音障碍和口吃严重程度评估量表-3）、运动功能（统一帕金森病评定量表 III[UPDRS-III]和 UPDRS-IV）、认知功能（简易精神状态检查[MMSE]、蒙特利尔认知评估[MoCA]、Stroop 颜色词测试、言语流畅性、数字跨度测试和线条定向）和日常生活活动能力。采用组间比较（独立 t 检验、Mann-Whitney U 检验或 χ²检验）和线性回归分析来确定重复言语障碍的临床相关性。
共有 65 名患者（57.5%）存在重复言语障碍。与无重复言语障碍的患者相比，有重复言语障碍的患者 UPDRS-III（P=0.049）、MoCA（P=0.030）和言语功能明显更差，左旋多巴等效日剂量（LEDD；P=0.031）更高。与无重复言语障碍的患者相比，重复言语障碍患者中男性明显更为常见（64.6%比 18.7%；P<0.001）。单变量和随后的多元线性回归分析表明，重复言语障碍的严重程度与性别（P<0.001）、MoCA（P=0.006）和言语变量（异常率，P=0.007；不精确辅音，P=0.043）显著相关，独立于疾病持续时间、UPDRS III 和 LEDD。
有重复言语障碍的 PD 患者的运动、认知和言语功能比无重复言语障碍的患者差。重复言语障碍的最主要影响因素可能是男性性别。
