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本文引用的文献

1
Syncope and sinus bradycardia from combined use of thalidomide and beta-blocker.沙利度胺与β受体阻滞剂联合使用导致的晕厥和窦性心动过缓。
Pharmacoepidemiol Drug Saf. 2008 Oct;17(10):1033-5. doi: 10.1002/pds.1624.
2
Effect of thalidomide on the expression of TNF-alpha m-RNA and synthesis of TNF-alpha in cells from leprosy patients with reversal reaction.沙利度胺对麻风反应期患者细胞中肿瘤坏死因子-α(TNF-α)信使核糖核酸(m-RNA)表达及TNF-α合成的影响。
Immunopharmacol Immunotoxicol. 2006;28(3):431-41. doi: 10.1080/08923970600928023.
3
Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India.麻风结节性红斑的临床病程:印度海得拉巴的一项11年队列研究
Am J Trop Med Hyg. 2006 May;74(5):868-79.
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Thalidomide: current status.沙利度胺:现状
Indian J Dermatol Venereol Leprol. 2006 Jan-Feb;72(1):75-80. doi: 10.4103/0378-6323.19732.
5
Adverse effects of thalidomide administration in patients with neoplastic diseases.沙利度胺用于肿瘤疾病患者时的不良反应。
Am J Med. 2004 Oct 1;117(7):508-15. doi: 10.1016/j.amjmed.2004.03.040.
6
Management of thalidomide toxicity.沙利度胺毒性的管理。
J Support Oncol. 2003 Sep-Oct;1(3):194-205.
7
Thalidomide-induced sinus bradycardia.沙利度胺诱发的窦性心动过缓。
Ann Pharmacother. 2003 Jul-Aug;37(7-8):1040-3. doi: 10.1345/aph.1D003.
8
The management of erythema nodosum leprosum: current and future options.麻风结节性红斑的管理:当前及未来的选择
Lepr Rev. 1996 Dec;67(4):253-9. doi: 10.5935/0305-7518.19960026.
9
Treatment of moderately severe erythema nodosum leprosum with clofazimine--a controlled trial.用氯法齐明治疗中度严重的麻风结节性红斑——一项对照试验。
Lepr Rev. 1971 Sep;42(3):167-77. doi: 10.5935/0305-7518.19710020.

沙利度胺致年轻结节性红斑麻风病患者心动过缓与剂量相关。

Dose-dependent thalidomide induced bradycardia in young erythema nodosum leprosum patient.

机构信息

Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Department of Clinical Division, Central Leprosy Teaching and Research Institute, Ministry of Health and Family Welfare, Chengalpattu, Tamilnadu, India.

出版信息

Indian J Pharmacol. 2019 Jan-Feb;51(1):72-74. doi: 10.4103/ijp.IJP_48_18.

DOI:10.4103/ijp.IJP_48_18
PMID:31031470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6444837/
Abstract

The distressing consequences of immunology in leprosy is the lepra reaction. Erythema nodosum leprosum(ENL) in special cases need to be managed with capsule thalidomide in varying doses. We report such a case of bradycardia in thalidomide dose dependent manner in a young ENL male.

摘要

麻风病免疫学的令人痛苦的后果是麻风反应。结节性红斑型麻风(ENL)在特殊情况下需要用不同剂量的胶囊沙利度胺进行治疗。我们报告了一例在 ENL 年轻男性中以沙利度胺剂量依赖性方式出现心动过缓的病例。