Tadesse Azeb, Abebe Markos, Bizuneh Elizabeth, Mulugeta Wondwossen, Aseffa Abraham, Shannon E J
Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
Immunopharmacol Immunotoxicol. 2006;28(3):431-41. doi: 10.1080/08923970600928023.
Hypersensitivity reactions called reversal reaction (RR) and erythema nodosum leprosum (ENL) occur in leprosy. They are characterized by an increase in tumor necrosis factor-alpha (TNF-alpha). Thalidomide is an effective treatment for ENL but not RR. Its effectiveness in ENL is attributed to inhibition of TNF-alpha, and this does not explain its failure to treat RR. We assessed thalidomide's effect on TNF-alpha in RR. Mononuclear cells from RR and non-RR patients and healthy individuals were treated with thalidomide and M.leprae (AFB), a cytosol fraction of M. leprae or Dharmendra lepromin. Thalidomide suppressed TNF-alpha, but when some RR patients' cells were stimulated with AFB, it enhanced TNF-alpha.
麻风病会出现称为逆转反应（RR）和麻风结节性红斑（ENL）的超敏反应。它们的特征是肿瘤坏死因子-α（TNF-α）增加。沙利度胺是治疗ENL的有效药物，但对RR无效。其对ENL的有效性归因于对TNF-α的抑制作用，而这并不能解释其治疗RR失败的原因。我们评估了沙利度胺对RR中TNF-α的影响。用沙利度胺和麻风分枝杆菌（抗酸杆菌，AFB）、麻风分枝杆菌的胞质溶胶部分或达曼德拉麻风菌素处理RR患者、非RR患者及健康个体的单核细胞。沙利度胺可抑制TNF-α，但当用AFB刺激一些RR患者的细胞时，它会增强TNF-α。
