Infectious Diseases and Immunity in Global Heath Program, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Front Cell Infect Microbiol. 2019 Apr 11;9:100. doi: 10.3389/fcimb.2019.00100. eCollection 2019.
genus protozoan parasites have developed various strategies to overcome host cell protective mechanisms favoring their survival and propagation. Recent findings in the field propose a new player in this infectious strategy, the exosomes. Exosomes are eukaryotic extracellular vesicles essential to cell communication in various biological contexts. In fact, there have been an increasing number of reports over the last 10 years regarding the role of protozoan parasite exosomes, exosomes included, in their capacity to favor infection and propagation within their hosts. In this review, we will discuss the latest findings regarding exosome function during infectious conditions with a strong focus on -host interaction from a mammalian perspective. We also compare the immunomodulatory properties of exosomes to other parasite exosomes, demonstrating the conserved, important role that exosomes play during parasite infection.
原生动物寄生虫属已开发出各种策略来克服有利于其生存和繁殖的宿主细胞保护机制。该领域的最新发现提出了一种新的感染策略，即外泌体。外泌体是真核细胞外囊泡，在各种生物环境中对细胞通讯至关重要。事实上，在过去 10 年中，关于原生动物寄生虫外泌体（包括外泌体）在促进其在宿主中感染和繁殖的能力方面的报告越来越多。在这篇综述中，我们将讨论有关感染条件下外泌体功能的最新发现，重点从哺乳动物的角度探讨-宿主相互作用。我们还将外泌体的免疫调节特性与其他寄生虫外泌体进行比较，证明了外泌体在寄生虫感染过程中所起的保守而重要的作用。
