• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种新型巴西利什曼原虫携带的不是全病毒，而是布尼亚病毒。

A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus.

作者信息

Kostygov Alexei Yu, Grybchuk Danyil, Heeren Senne, Gerasimov Evgeny S, Klocek Donnamae, Reddy Aditya, Sádlová Jovana, Pacáková Lenka, Kohl Alain, Stejskal František, Volf Petr, Dujardin Jean-Claude, Yurchenko Vyacheslav

机构信息

Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia.

Zoological Institute of the Russian Academy of Sciences, St. Petersburg, Russia.

出版信息

PLoS Negl Trop Dis. 2024 Dec 27;18(12):e0012767. doi: 10.1371/journal.pntd.0012767. eCollection 2024 Dec.

DOI:10.1371/journal.pntd.0012767
PMID:39729426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11717295/
Abstract

Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.

摘要

利什曼原虫属锥虫科，包含专性寄生的鞭毛虫，可引发多种媒介传播疾病，统称为利什曼病。症状从相对无害的皮肤损伤到内脏器官完全衰竭不等。如果寄生虫携带假病毒科的利什曼原虫RNA病毒（LRV），病情会加重。在筛选巴西利什曼原虫的一种新分离株时，我们发现它携带的不是全病毒，而是白蛉病毒科的一种布尼亚病毒。据我们所知，这是首次发现布尼亚病毒感染维安尼亚利什曼原虫亚属的一个代表种。我们认为这些病毒可能是美洲利什曼病潜在的致病因素，并鼓励研究人员不仅要检测利什曼原虫菌株中是否存在LRV，还要检测其他RNA病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/6478f768c8f2/pntd.0012767.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/b3b74d2ce618/pntd.0012767.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/f7935c975add/pntd.0012767.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/8ade58d1b58e/pntd.0012767.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/1cf87347152b/pntd.0012767.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/6478f768c8f2/pntd.0012767.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/b3b74d2ce618/pntd.0012767.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/f7935c975add/pntd.0012767.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/8ade58d1b58e/pntd.0012767.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/1cf87347152b/pntd.0012767.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d98/11717295/6478f768c8f2/pntd.0012767.g005.jpg

相似文献

1
A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus.一种新型巴西利什曼原虫携带的不是全病毒，而是布尼亚病毒。
PLoS Negl Trop Dis. 2024 Dec 27;18(12):e0012767. doi: 10.1371/journal.pntd.0012767. eCollection 2024 Dec.
2
Leishmania (Viannia) braziliensis is the predominant species infecting patients with American cutaneous leishmaniasis in the State of Minas Gerais, Southeast Brazil.巴西利什曼原虫（维安尼亚亚属）是巴西东南部米纳斯吉拉斯州感染美洲皮肤利什曼病患者的主要物种。
Acta Trop. 1999 Apr 30;72(3):251-8. doi: 10.1016/s0001-706x(98)00100-4.
3
Leishmania (Viannia) braziliensis is the prevalent species infecting patients with tegumentary leishmaniasis from Mato Grosso State, Brazil.巴西利什曼原虫（维安尼亚亚属）是感染巴西马托格罗索州皮肤利什曼病患者的主要病原体。
Acta Trop. 2006 Jul;98(3):277-85. doi: 10.1016/j.actatropica.2006.06.001. Epub 2006 Jul 17.
4
Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors.巴西利什曼原虫（维阿尼亚种）的基因变异株表现出不同的生物学行为。
Parasitol Res. 2018 Oct;117(10):3157-3168. doi: 10.1007/s00436-018-6014-4. Epub 2018 Jul 18.
5
Association between an emerging disseminated form of leishmaniasis and Leishmania (Viannia) braziliensis strain polymorphisms.新型播散性利什曼病与利什曼原虫（Viannia）巴西利ensis 株多态性之间的关联。
J Clin Microbiol. 2012 Dec;50(12):4028-34. doi: 10.1128/JCM.02064-12. Epub 2012 Oct 3.
6
Leishmania RNA Virus Is Not Detected in All Species of the Leishmania Viannia Subgenus: The Case of L. (V.) panamensis in Colombia.利什曼原虫 RNA 病毒并未在所有属于利什曼原虫威尼亚亚属的物种中被检测到：以哥伦比亚的 L.（V.）panamensis 为例。
Am J Trop Med Hyg. 2023 Jan 30;108(3):555-560. doi: 10.4269/ajtmh.22-0551. Print 2023 Mar 1.
7
The isolation and molecular characterization of Leishmania spp. from patients with American tegumentary leishmaniasis in northwest Argentina.从阿根廷西北部的美洲皮肤利什曼病患者中分离和分子特征分析利什曼原虫。
Acta Trop. 2014 Mar;131:16-21. doi: 10.1016/j.actatropica.2013.11.015. Epub 2013 Nov 27.
8
Presence of parasite DNA in clinically unaffected nasal mucosa during cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis.在巴西利什曼原虫（Leishmania）引起的皮肤利什曼病期间，临床无影响的鼻腔黏膜中存在寄生虫 DNA。
Clin Microbiol Infect. 2019 Apr;25(4):515.e5-515.e7. doi: 10.1016/j.cmi.2018.12.027. Epub 2019 Jan 4.
9
Evaluation of a Multilocus Sequence Typing (MLST) scheme for Leishmania (Viannia) braziliensis and Leishmania (Viannia) panamensis in Colombia.哥伦比亚巴西利什曼原虫（维安亚属）和巴拿马利什曼原虫（维安亚属）多位点序列分型（MLST）方案的评估
Parasit Vectors. 2017 May 12;10(1):236. doi: 10.1186/s13071-017-2175-8.
10
A preliminary study aimed at the detection of Leishmania parasites in subjects with cutaneous leishmaniasis using polymerase chain reaction.一项旨在利用聚合酶链反应检测皮肤利什曼病患者体内利什曼原虫寄生虫的初步研究。
J Dermatol. 1998 May;25(5):290-8. doi: 10.1111/j.1346-8138.1998.tb02400.x.

本文引用的文献

1
Promotion of order to class to accommodate a rapidly increasing number of related polyploviricotine viruses.为了容纳数量迅速增加的相关多质多病毒，将其提升到目。
J Virol. 2024 Oct 22;98(10):e0106924. doi: 10.1128/jvi.01069-24. Epub 2024 Sep 20.
2
Epidemiology and Genetic Characterization of RNA Virus in () spp. Isolates from Cutaneous Leishmaniasis Endemic Areas in Panama.巴拿马皮肤利什曼病流行地区()物种分离株中RNA病毒的流行病学和基因特征
Microorganisms. 2024 Jun 27;12(7):1317. doi: 10.3390/microorganisms12071317.
3
Identification of diverse RNA viruses in flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae).
在鞭毛虫（眼虫纲：锥虫科：芽殖短膜虫亚科）中鉴定多种RNA病毒。
Virus Evol. 2024 May 4;10(1):veae037. doi: 10.1093/ve/veae037. eCollection 2024.
4
Diversity and dissemination of viruses in pathogenic protozoa.致病原生动物中的病毒多样性和传播。
Nat Commun. 2023 Dec 15;14(1):8343. doi: 10.1038/s41467-023-44085-2.
5
The effects of Leishmania RNA virus 2 (LRV2) on the virulence factors of L. major and pro-inflammatory biomarkers: an in vitro study on human monocyte cell line (THP-1).利什曼原虫 RNA 病毒 2（LRV2）对大沙鼠利什曼原虫毒力因子和促炎生物标志物的影响：体外研究人单核细胞系（THP-1）。
BMC Microbiol. 2023 Dec 14;23(1):398. doi: 10.1186/s12866-023-03140-0.
6
Phylogenetic framework to explore trait evolution in Trypanosomatidae.用于探索锥虫科性状进化的系统发育框架。
Trends Parasitol. 2024 Feb;40(2):96-99. doi: 10.1016/j.pt.2023.11.009. Epub 2023 Dec 7.
7
First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil.巴西东南部犬内脏利什曼病和人内脏利什曼病病例中利什曼原虫 RNA 病毒 2（LRV2）的首次报告。
Mem Inst Oswaldo Cruz. 2023 Sep 18;118:e230071. doi: 10.1590/0074-02760230071. eCollection 2023.
8
RNA viruses of Crithidia bombi, a parasite of bumblebees.熊蜂寄生虫——克氏锥虫的RNA病毒。
J Invertebr Pathol. 2023 Nov;201:107991. doi: 10.1016/j.jip.2023.107991. Epub 2023 Sep 13.
9
Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris.在世界性单性寄生的锥虫 Leptomonas pyrrhocoris 中 RNA 病毒的多样性。
BMC Biol. 2023 Sep 12;21(1):191. doi: 10.1186/s12915-023-01687-y.
10
Kinetoplast Genome of spp. Is under Strong Purifying Selection.锥虫属物种的动质体基因组处于强烈的纯化选择之下。
Trop Med Infect Dis. 2023 Jul 27;8(8):384. doi: 10.3390/tropicalmed8080384.