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女性不孕的最新药物治疗方法。

State of the art and emerging drug therapies for female infertility.

机构信息

Department of Obstetrics & Gynaecology, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.

G.EN.E.R.A. Centers for Reproductive Medicine, Rome, Italy.

出版信息

Gynecol Endocrinol. 2019 Oct;35(10):835-841. doi: 10.1080/09513590.2019.1603289. Epub 2019 Apr 29.

Abstract

At present, infertility is a key-issue. When applicable, fertilization (IVF) has become the standard approach to treat this condition but a thorough investigation and, whenever possible, the individual diagnosis of the underlying causes of infertility are required. For many female causes, indeed, efficient medical therapies are available to achieve a fast solution of the problem. This review is based on the relevant literature indexed in PubMed and SCOPUS and is focused on the most recent clinical literature on the treatment of women (and couples) affected from infertility. The reduction in IVF treatment burden and risks are now considered pivotal to set 'patient-friendly' therapies and represent crucial issues for both patients and physicians. To this end, the researchers are now focusing their attention on old drugs with new indications and new compounds with more appropriate functions, to improve the compliance of the women and reduce the burden of infertility, a condition that is becoming an important issue in the modern world, also for the Public Health System.

摘要

目前,不孕不育是一个关键问题。在适用的情况下,受精(试管婴儿)已成为治疗这种情况的标准方法,但需要彻底调查,并在可能的情况下对不孕不育的潜在原因进行个体化诊断。对于许多女性原因,确实有有效的医疗疗法可以快速解决问题。本综述基于 PubMed 和 SCOPUS 索引的相关文献,重点关注最近关于治疗不孕不育女性(和夫妇)的临床文献。降低试管婴儿治疗的负担和风险现在被认为是制定“患者友好型”疗法的关键,这是患者和医生都关心的关键问题。为此,研究人员现在将注意力集中在具有新适应症的旧药物和具有更合适功能的新化合物上,以提高女性的顺应性并减轻不孕不育的负担,这种情况在现代世界变得越来越重要,对公共卫生系统也是如此。

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