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面部和头皮基底细胞癌的治疗:文献综述

Face and Scalp Basal Cell Carcinoma Treatment: A Review of the Literature.

作者信息

Bernardini Nicoletta, Skroza Nevena, Zuber Sara, Tolino Ersilia, Balduzzi Veronica, Mambrin Alessandra, Marchesiello Anna, Anzalone Alessia, Colapietra Daniela, Proietti Ilaria, Potenza Concetta

机构信息

Prof. Nevena Skroza, MD, PhD, Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Polo Pontino, 04019 Terracina, Italy;

出版信息

Acta Dermatovenerol Croat. 2019 Mar;27(1):22-27.

Abstract

Basal cell carcinoma (BCC) is the most frequent skin cancer and is characterized by slow growth, even if it can be locally invasive and rarely metastasizes. Many different phenotypic presentations and histopathologic subtypes have been described, and the current guidelines subdivide BCCs into low-risk (nodular and superficial) and high-risk subtypes (micronodular, infiltrating, and morphoeic BCC and those with squamous differentiation). Dermoscopy allows the identification of the features associated with these different subtypes. Compared with the low-risk forms of BCC, more aggressive ones tend to undergo more frequently incomplete surgical excision and perineural invasion, so the identification of these lesions before surgery is extremely important. The gold standard of treatment is surgery, particularly for the H region of the face and infiltrative lesions, but other options are available and selected according to many variables, including body area, age, comorbidities, and clinical, dermoscopic, and histopathological features of the lesion. Moreover, the possible complications of surgical approaches, namely healing defects, failure of skin grafts, and wound infection, should be considered. In this review we discuss the management of BCC localized on the face and scalp, according to the currently available treatment options.

摘要

基底细胞癌(BCC)是最常见的皮肤癌,其特点是生长缓慢,尽管它可能具有局部侵袭性且很少发生转移。已经描述了许多不同的表型表现和组织病理学亚型,当前指南将BCC分为低风险(结节性和浅表性)和高风险亚型(微结节性、浸润性和硬斑病样BCC以及具有鳞状分化的BCC)。皮肤镜检查可识别与这些不同亚型相关的特征。与低风险形式的BCC相比,侵袭性更强的BCC往往更频繁地出现手术切除不完全和神经周围侵犯的情况,因此在手术前识别这些病变极其重要。治疗的金标准是手术,特别是对于面部的H区域和浸润性病变,但也有其他选择,会根据许多变量来选择,包括身体部位、年龄、合并症以及病变的临床、皮肤镜和组织病理学特征。此外,还应考虑手术方法可能出现的并发症,即愈合缺陷、皮肤移植失败和伤口感染。在本综述中,我们根据目前可用的治疗选择讨论面部和头皮上局限性BCC的管理。

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