Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Glia. 2019 Sep;67(9):1625-1636. doi: 10.1002/glia.23622. Epub 2019 Apr 29.
This review discusses aspects of known and putative compartmentalized 3',5'-cyclic adenosine monophosphate (cAMP) signaling in astrocytes, a cell type that has turned out to be a key player in brain physiology and pathology. cAMP has attracted less attention than Ca in recent years, but could turn out to rival Ca in its potential to drive cellular functions and responses to intra- and extracellular cues. Further, Ca and cAMP are known to engage in extensive crosstalk and cAMP signals often take place within subcellular compartments revolving around multi-protein signaling complexes; however, we know surprisingly little about this in astrocytes. Here, we review aspects of astrocytic cAMP signaling, provide arguments for an increased interest in this subject, suggest possible future research directions within the field, and discuss putative drug targets.
这篇综述讨论了星形胶质细胞中已知和假定的分隔 3'，5'-环腺苷酸 (cAMP) 信号转导的各个方面，星形胶质细胞已成为脑生理学和病理学中的关键参与者。近年来，cAMP 引起的关注不如 Ca 多，但它有可能在驱动细胞功能和对细胞内外信号的反应方面与 Ca 相媲美。此外，Ca 和 cAMP 已知存在广泛的串扰，cAMP 信号通常发生在围绕多蛋白信号复合物的亚细胞隔室内；然而，我们对星形胶质细胞中的这方面知之甚少。在这里，我们综述了星形胶质细胞 cAMP 信号转导的各个方面，为增加对这一主题的兴趣提供了论据，提出了该领域内可能的未来研究方向，并讨论了潜在的药物靶点。
