Switching from a fumaric acid ester mixture to dimethylfumarate monotherapy in psoriasis.
作者信息
Warren R B, Barker J N W, Van de Kerkhof P, Reich K, Mrowietz U
机构信息
Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR Biomedical Research Centre, University of Manchester, Manchester, UK.
St John's Institute of Dermatology, King's College London, London, UK.
出版信息
J Eur Acad Dermatol Venereol. 2019 Oct;33(10):e352-e353. doi: 10.1111/jdv.15644. Epub 2019 May 10.
Abstract
摘要
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Switch of psoriasis therapy from a fumaric acid ester mixture to dimethyl fumarate monotherapy: Results of a prospective study.从富马酸酯混合物转换为富马酸二甲酯单药治疗银屑病：一项前瞻性研究的结果。
J Dtsch Dermatol Ges. 2019 Sep;17(9):906-912. doi: 10.1111/ddg.13749. Epub 2019 Jan 15.
2
S3 Guideline for the treatment of psoriasis vulgaris, update - Short version part 1 - Systemic treatment.S3 寻常型银屑病治疗指南更新版——短版 1 部分：系统治疗。
J Dtsch Dermatol Ges. 2018 May;16(5):645-669. doi: 10.1111/ddg.13516.
3
Dimethyl fumarate (DMF) vs. monoethyl fumarate (MEF) salts for the treatment of plaque psoriasis: a review of clinical data.富马酸二甲酯（DMF）与富马酸单乙酯（MEF）盐治疗斑块状银屑病的临床数据比较。
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Trends Pharmacol Sci. 2018 Jan;39(1):1-12. doi: 10.1016/j.tips.2017.11.002. Epub 2017 Nov 25.
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Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm - and placebo-controlled trial (BRIDGE).LAS41008（富马酸二甲酯）治疗成人中重度慢性斑块型银屑病的疗效和安全性：一项随机、双盲、富马酸二甲酯和安慰剂对照试验（BRIDGE）。
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DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner.二甲基富马酸盐（DMF）而非其他富马酸盐，在体外以不依赖Nrf2的方式抑制核因子κB（NF-κB）活性。
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