Han Yulin, Zhao Yichuan, Ma Shengming
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P.R. China.
Research Center for Molecular Recognition and Synthesis, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P.R. China.
Chemistry. 2019 Jul 17;25(40):9529-9533. doi: 10.1002/chem.201900963. Epub 2019 Jun 17.
An efficient chirality transfer in the [RhCl(CO) ] -catalyzed [2+2+1] cyclization of optically active axially chiral 1,3-disubstituted allenynes with CO to access optically active bicyclopentenone compounds has been developed. The distal C=C bond of allenes reacted with the alknye unit and CO to afford [4.3.0]-bicyclic products with high ee values under mild reaction conditions with an excellent selectivity.
已开发出一种在[RhCl(CO)]催化下，光学活性轴向手性1,3 - 二取代联烯炔与CO进行[2+2+1]环化反应以得到光学活性双环戊烯酮化合物的有效手性转移方法。在温和的反应条件下，联烯的远端C = C键与炔基单元和CO反应，以优异的选择性得到具有高对映体过量值（ee值）的[4.3.0] - 双环产物。
