Dardiotis Efthimios, Siokas Vasileios, Aloizou Athina-Maria, Karampinis Emmanouil, Brotis Alexandros G, Grigoriadis Savas, Paterakis Konstantinos, Dardioti Maria, Komnos Apostolos, Kapsalaki Eftychia, Fountas Kostas, Hadjigeorgiou Georgios M
a Department of Neurology, Laboratory of Neurogenetics , University of Thessaly, University Hospital of Larissa , Larissa , Greece.
b Department of Neurosurgery , University of Thessaly, University Hospital of Larissa , Larissa , Greece.
Brain Inj. 2019;33(7):836-845. doi: 10.1080/02699052.2019.1606444. Epub 2019 Apr 29.
Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain. To examine the role of integrin-AV () and integrin-B8 () tag single nucleotide polymorphisms (SNPs) on the outcome of patients with TBI. 363 participants were included and genotyped for 11 SNPs for and 11 for gene. SNPs were tested for associations with the 6-month outcome after TBI, the presence of a hemorrhagic event after TBI, and the initial TBI severity after adjustment for TBI's main predictors. The ITGAV CC and GG genotypes were associated with an unfavorable outcome after TBI, compared to the TT and AA genotypes, respectively. The ITGB8 CC and CC genotypes were associated with increased risk of any cerebral hemorrhagic event after TBI compared to GG and TT respectively. The ITGAV and were associated with the TBI's initial severity. ITGAV gene SNPs may be implicated in the outcome after TBI, as well as in the initial TBI severity, and also of ITGB8 gene SNPs in the risk of hemorrhagic event after a TBI.
少数基因变异与创伤性脑损伤（TBI）后的预后相关。整合素是糖蛋白受体，在脑微血管完整性中起重要作用。为了研究整合素αV（ITGAV）和整合素β8（ITGB8）标签单核苷酸多态性（SNP）对TBI患者预后的作用。纳入了363名参与者，并对ITGAV基因的11个SNP和ITGB8基因的11个SNP进行基因分型。测试SNP与TBI后6个月的预后、TBI后出血事件的发生以及在对TBI的主要预测因素进行调整后的初始TBI严重程度之间的关联。与TT和AA基因型相比，ITGAV基因的CC和ITGB8基因的GG基因型分别与TBI后不良预后相关。与GG和TT基因型相比，ITGB8基因的CC和CC基因型分别与TBI后任何脑出血事件的风险增加相关。ITGAV基因的SNP与TBI的初始严重程度相关。ITGAV基因的SNP可能与TBI后的预后以及初始TBI严重程度有关，ITGB8基因的SNP也与TBI后出血事件的风险有关。
