Department of Medicine, University of California , San Diego, La Jolla , CA , USA.
Department of Anesthesiology, University of Colorado , Aurora , CO , USA.
J Environ Sci Health B. 2019;54(8):623-639. doi: 10.1080/03601234.2019.1596001. Epub 2019 Apr 29.
There is need to understand biological markers and mechanisms in Gulf War illness (GWI). To examine whether and how eicosanoids - prostaglandins and leukotrienes - are altered in veterans with GWI. Seventy participants including 37 GWI and 33 healthy controls, shared exposure information, and had plasma eicosanoids assessed - prostaglandin F2 alpha (), prostaglandin D2 (), leukotriene B4 () among others. Values were compared for GWI versus controls. Eicosanoid intercorrelations were compared in cases vs. controls. For the most significantly altered eicosanoid in GWI, exposure and symptom relations were assessed. Prostaglandins and leukotrienes were depressed in GWI, strongest for pgf2α, then lb4. Eicosanoid intercorrelations differed in GWI vs. controls. Fuel-solvent, pesticide, radioactive chemicals and metal exposures related negatively to pgf2α; as, in GWI, did chemical attack and vaccines. Multivariate predictors included fuels-solvents and radioactive chemicals (negative); tetanus vaccine and herbicides (positive). Fuels-solvents and radioactive chemicals predicted lower pgf2α in cases, controls, and all participants controlled for case status. Lower pgf2α related to GWI "Kansas criteria" domains of pain, respiratory, and (borderline significantly) skin symptoms. Multiple eicosanoids are depressed in GWI, particularly pgf2α and lb4. Prior fuel-solvent exposures, radioactive chemicals, and (in GWI cases) vaccines were linked to lower pgf2α.
有必要了解海湾战争病（GWI）中的生物标志物和机制。 检查在患有 GWI 的退伍军人中，类二十烷酸（eicosanoids） - 前列腺素和白三烯 - 是否以及如何发生改变。 包括 37 名 GWI 患者和 33 名健康对照者在内的 70 名参与者，共享了暴露信息，并评估了血浆类二十烷酸 - 前列腺素 F2α（），前列腺素 D2（），白三烯 B4（）等。 比较了 GWI 患者与对照组的数值。 比较了病例与对照组之间的类二十烷酸相互关系。 对于 GWI 中变化最明显的类二十烷酸，评估了暴露和症状的关系。 在 GWI 中，前列腺素和白三烯减少，pgf2α 最强，然后是 lb4。 类二十烷酸在 GWI 中与对照组的相互关系不同。 燃料溶剂，农药，放射性化学物质和金属暴露与 pgf2α 呈负相关； 在 GWI 中，化学攻击和疫苗也是如此。 多变量预测因子包括燃料溶剂和放射性化学物质（负）； 破伤风疫苗和除草剂（正）。 燃料溶剂和放射性化学物质可预测病例，对照者和所有参与者中 pgf2α 降低，病例状态得到控制。 较低的 pgf2α 与 GWI“堪萨斯标准”的疼痛，呼吸和（边缘显著）皮肤症状领域有关。 多种类二十烷酸在 GWI 中减少，尤其是 pgf2α 和 lb4。 先前的燃料溶剂暴露，放射性化学物质以及（在 GWI 病例中）疫苗与 pgf2α 降低有关。
