Boston University School of Medicine, United States of America; VA Boston Healthcare System, Boston, MA, United States of America.
Boston University School of Public Health, Boston, MA, United States of America.
Life Sci. 2021 Sep 1;280:119623. doi: 10.1016/j.lfs.2021.119623. Epub 2021 May 15.
This study analyzed deployment-related exposures and risk of Persian Gulf War Illness (GWI) in women veterans from the Veterans Affairs (VA) Cooperative Studies Program 585 Gulf War Era Cohort and Biorepository (GWECB CSP#585).
We examined the associations between GW deployment-related exposures and case definitions for GWI in deployed GW women. Multivariate regression analyses controlling for demographic outcomes were performed.
Surveys were obtained from 202 GW deployed women veterans. Self-reported exposure to smoke from oil well fires as well as chemical and biological warfare were the only exposures significantly associated with the Center for Disease Control and Prevention (CDC) GWI criteria. Seventy-nine women were excluded from the rest of the analyses as they met Kansas GW illness exclusion criteria. Eligible women who self-reported deployment-related exposure to smoke from oil wells, pyridostigmine bromide (PB) pills, pesticide cream, pesticide treated uniforms, and insect baits were significantly more likely to meet the Kansas GWI criteria (n = 123) than those unexposed and exposures were related to Kansas symptom subdomain endorsements.
These results suggest that women GW veterans reporting deployment related exposures of pesticide, oil well fire and PB pills are significantly more likely to meet the Kansas GWI criteria in this national cohort of GW women suggesting its utility in future studies. In addition, based on these results it appears that women exposed to particular toxicants during the war may benefit from more targeted treatment strategies dependent upon the mechanism of exposure of their toxicant induced outcomes.
本研究通过退伍军人事务部（VA）合作研究计划 585 号海湾战争时代队列和生物库（GWECB CSP#585）分析了与部署相关的暴露和波斯湾战争疾病（GWI）风险在女性退伍军人中的作用。
我们检查了 GW 部署相关暴露与 deployed GW 女性的 GWI 病例定义之间的关联。进行了多变量回归分析，控制了人口统计学结果。
从 202 名 GW 部署的女性退伍军人中获得了调查。自我报告接触油井火灾烟雾以及化学和生物战剂是唯一与疾病控制与预防中心（CDC）GWI 标准显著相关的暴露。由于符合堪萨斯州 GWI 排除标准，有 79 名女性被排除在其余分析之外。自我报告与接触油井烟雾、吡哆醇溴化物（PB）药丸、农药霜剂、农药处理制服和昆虫诱饵相关的部署相关暴露的合格女性更有可能符合堪萨斯州 GWI 标准（n=123），而未暴露于这些暴露因素的女性以及这些暴露与堪萨斯州症状子域的认可相关。
这些结果表明，报告与部署相关的暴露于杀虫剂、油井火灾和 PB 药丸的女性 GW 退伍军人更有可能符合该国家 GW 女性队列中的堪萨斯州 GWI 标准，这表明其在未来研究中的实用性。此外，基于这些结果，似乎在战争期间暴露于特定有毒物质的女性可能会受益于更有针对性的治疗策略，具体取决于其有毒物质引起的结果的暴露机制。
