Vesper B, Rohde W, Groot-Wassink T
Zentralbl Gynakol. 1986;108(23):1442-52.
Synthetic LH/RH Gonadorelin, produced by VEB Berlin-Chemie, was given to 11 women with a normal menstrual cycle during the middle of the follicle phase. It was proved as a very effective drug, which provoked a typical gonadotropin release. Also 10 patients with a secondary amenorrhea responded already to the first intravenous injection of 80 micrograms Gonadorelin with a peak level of gonadotropins, in particular with LH levels, after 30 to 60 minutes (delta 1 = 1 st peak level--0' level). The relative ascent of gonadotropins (delta 2 = 2nd peak level--120' level) after the second step i.v. administration of 80 micrograms Gonadorelin at a 120 minutes interval was not significantly higher than delta 1. The reaction of pituitary on LH/RH does not immediately depend on the basal level of gonadotropin values. It reflects the severity of the hypothalamic-pituitary functional disturbance. The "Gonadorelin-test" ist a good complement to the progesterone- and clomiphene-test.
由东德科学院柏林化学制药厂生产的合成促黄体激素释放激素（LH/RH）戈那瑞林，在卵泡期中期给予11名月经周期正常的女性。结果证明它是一种非常有效的药物，能引发典型的促性腺激素释放。另外，10名继发性闭经患者在首次静脉注射80微克戈那瑞林后，30至60分钟时促性腺激素达到峰值水平，尤其是促黄体生成素（LH）水平（δ1 = 第一个峰值水平 - 0' 水平）。在120分钟间隔时第二步静脉注射80微克戈那瑞林后，促性腺激素的相对上升幅度（δ2 = 第二个峰值水平 - 120' 水平）并不显著高于δ1。垂体对LH/RH的反应并不直接取决于促性腺激素值的基础水平。它反映了下丘脑 - 垂体功能紊乱的严重程度。“戈那瑞林试验”是对孕酮试验和克罗米芬试验的良好补充。
