Smiljanić N, Ciglar S, Jagarinac N
Jugosl Ginekol Opstet. 1979 Jan-Feb;18(1):21-7.
Forty-three patients with secondary hypothalamic amenorrhea and 17 healthy women in the early and late folliculin phases of the normal cycle were tested with 100 micrograms synthetic LH-RH i. m. The LH and FSH concentration in the plasma was measured before and after the injection of synthetic LH-RH. The patients were divided into two groups, according to the degree of estrogen deficit. The basal concentration and maximum LH increase in the group of hypothalamic amenorrhea with a milder estrogen deficit proved to be significantly higher than in the group with a higher estrogen deficit (22.2 +/- 7.2 versus 12.7 +/- 9,3 p less than 0.01 and, respectively, 74.8 +/- 17.00 versus 34.4 +/- 11.2, p less than 0.01). In healthy women with the normal cycle, the basal LH and FSH concentrations and the maximum increase after the LH-RH application were significantly higher in the late than in the early folliculin phase. The basal LH and FSH concentrations and their increase after the LH-RH injection appear to depend on the concentration of endogenous estrogens, both in normal cycle and in secondary hypothalamic amenorrhea.
43例继发性下丘脑性闭经患者及17例处于正常周期卵泡期早期和晚期的健康女性，接受了100微克合成促黄体生成素释放激素（LH-RH）的肌肉注射。在注射合成LH-RH前后，测定血浆中的促黄体生成素（LH）和促卵泡生成素（FSH）浓度。根据雌激素缺乏程度，将患者分为两组。雌激素缺乏较轻的下丘脑性闭经组的基础浓度和LH最大增加值，被证明显著高于雌激素缺乏较高的组（分别为22.2±7.2与12.7±9.3，p＜0.01；以及74.8±17.00与34.4±11.2，p＜0.01）。在正常周期的健康女性中，LH-RH应用后的基础LH和FSH浓度以及最大增加值在卵泡期晚期显著高于早期。在正常周期和继发性下丘脑性闭经中，基础LH和FSH浓度及其在LH-RH注射后的增加值似乎取决于内源性雌激素的浓度。
