Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service.
Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.
Curr Opin HIV AIDS. 2019 Jul;14(4):233-239. doi: 10.1097/COH.0000000000000559.
Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including both Fab and Fc-mediated antibody responses. We also highlight recent studies showing the interplay between these functions, focusing primarily on studies published in the last year.
Identification and characterization of bNAb donors continues to provide insights into viral factors that are potentially translatable to vaccine design. Improved and more diverse measures of Fc effector function, and modulators thereof, are enabling a deeper understanding of their role in infection. New data providing mechanistic links between the innate and adaptive humoral immune responses are creating exciting opportunities for vaccine strategies, with the aim of eliciting a polyfunctional protective response.
New insights into the overall humoral response to HIV infection are defining diverse and synergistic mechanisms required for antibody protection from HIV through vaccination.
目的综述：虽然预防性 HIV 疫苗设计的主要目标是诱导广泛中和抗体（bnAbs），但最近的证据表明，保护性反应也将受益于 Fc 效应功能。在这里，我们提供了 HIV 感染的抗体反应的最新更新，包括 Fab 和 Fc 介导的抗体反应。我们还强调了最近的研究，这些研究显示了这些功能之间的相互作用，主要集中在去年发表的研究上。
最近的发现：鉴定和表征 bnAb 供体继续提供有关病毒因素的见解，这些因素可能转化为疫苗设计。改进和更多样化的 Fc 效应功能措施及其调节剂，使人们能够更深入地了解它们在感染中的作用。新的数据提供了先天和适应性体液免疫反应之间的机制联系，为疫苗策略创造了令人兴奋的机会，旨在引发多效性的保护性反应。
总结：对 HIV 感染的整体体液反应的新见解正在通过疫苗接种定义通过抗体预防 HIV 所需的多样化和协同机制。
