Osváth P, Kelenhegyi K, Micskey E
Allergol Immunopathol (Madr). 1986 Nov-Dec;14(6):515-8.
The authors treated 17 food allergic, 2-14 year old children with chemoprophylactic drugs. The patients got either ketotifen or DSCG in random allocated for 4 weeks and thereafter a washout period of 2 weeks separated the trial period of the other drug. Oral challenge with the food was performed before the trial period and after a 4 week lasting elimination diet on the last day of each treatment. After the ketotifen therapy in 10 of the 17 patients no symptoms appeared after the challenge, whereas only 5 patients were completely protected by DSCG. However, with regards to isolated organ symptoms the two drugs were of equal value. In case of failure of one drug the other was effective with two exceptions. Symptoms of intolerance (vomiting, angioedema or abdominal cramps) occurred in 3 patients during DSCG treatment and in one of those getting ketotifen. In 3 cases of severe milk allergy (Heiner-Holland syndrome) symptom-free state could be attained only if diet was supplemented by ketotifen. Symptoms of food allergy can be well prevented in children through ketotifen therapy more than by DSCG.
作者对17名2至14岁的食物过敏儿童使用化学预防药物进行治疗。患者被随机分配服用酮替芬或色甘酸钠，为期4周，之后有2周的洗脱期，然后再进行另一种药物的试验期。在试验期之前以及每种治疗的最后一天进行为期4周的排除饮食后，对食物进行口服激发试验。在17名患者中，10名患者在接受酮替芬治疗后激发试验未出现症状，而只有5名患者被色甘酸钠完全保护。然而，就孤立器官症状而言，两种药物价值相当。在一种药物治疗失败的情况下，另一种药物有效，但有两个例外。在色甘酸钠治疗期间，3名患者出现不耐受症状（呕吐、血管性水肿或腹部绞痛），接受酮替芬治疗的患者中有1名出现此类症状。在3例严重牛奶过敏（海纳 - 霍兰德综合征）病例中，只有在饮食中添加酮替芬才能达到无症状状态。与色甘酸钠相比，通过酮替芬治疗能更好地预防儿童食物过敏症状。
