Boner A L, Richelli C, Antolini I, Vibelli C, Andri L
Ann Allergy. 1986 Jul;57(1):61-4.
The effectiveness of oral ketotifen was compared with that of placebo in 26 patients with food allergy in a randomized, double-blind parallel study. Patients were selected on the basis of food allergy as established by history, clinical improvement after an exclusion diet, and reappearance of the symptoms after a challenge with the food. Thirteen patients were given ketotifen and 13, placebo. Ketotifen or placebo were administered twice daily for 1 month after the first oral provocation test and the last dose was given 12 hours before the second oral provocation test. Ketotifen protected patients (7/13) significantly more than placebo (2/13; P less than .05). The results of this study suggest that ketotifen may be useful for some patients with food allergy.
在一项随机、双盲平行研究中，对26例食物过敏患者比较了口服酮替芬与安慰剂的疗效。根据病史确定为食物过敏、排除饮食后临床症状改善以及食物激发试验后症状再次出现来选择患者。13例患者给予酮替芬，13例给予安慰剂。在第一次口服激发试验后，酮替芬或安慰剂每日服用两次，共1个月，最后一剂在第二次口服激发试验前12小时服用。与安慰剂组（2/13）相比，酮替芬显著保护了更多患者（7/13；P<0.05）。本研究结果表明，酮替芬可能对某些食物过敏患者有用。
