Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Microcirculation. 2019 Jul;26(5):e12551. doi: 10.1111/micc.12551. Epub 2019 May 16.
This Special Topics Issue of the journal "Microcirculation" presents seven manuscripts spanning multiple perspectives of investigation. The first two manuscripts present technical/analytical approaches to determining and quantifying vascular network structure, and the third presents a methodology for determining intravascular hemodynamics within the in situ microvascular network. The fourth manuscript utilizes complexity analyses to determine changes in microvascular perfusion as a predictor of disease severity, while the fifth study links the changes to perfusion complexity to tissue metabolic demand and potential limitations on mitochondrial metabolism within skeletal muscle. The sixth manuscript further addresses this critical topic, providing a state-of-the-art discussion of skeletal muscle oxygen kinetics and the factors that impact this vital process. The final manuscript outlines the impact of the deletion of Robo4 on the vascular endothelium on microvascular function in white adipose tissue and the potentially beneficial effects for anti-obesity treatment. We hope that this presentation of issues of "Complexity in the Microcirculation" will be beneficial to the reader.
本期《微循环杂志》特刊收录了七篇文章，从多个角度探讨了微循环领域的研究。前两篇文章介绍了用于确定和量化血管网络结构的技术/分析方法，第三篇文章则提出了一种在原位微血管网络中确定血管内血液动力学的方法。第四篇文章利用复杂性分析来确定微血管灌注的变化作为疾病严重程度的预测指标，而第五项研究则将灌注复杂性的变化与组织代谢需求以及骨骼肌中线粒体代谢的潜在限制联系起来。第六篇文章进一步探讨了这个关键问题，对骨骼肌氧动力学及其影响这一重要过程的因素进行了详尽的讨论。最后一篇文章概述了 Robo4 缺失对白色脂肪组织微血管功能的影响，以及这种缺失对肥胖症治疗可能产生的有益效果。我们希望本期“微循环中的复杂性”专题能对读者有所帮助。
