Payne Geoffrey W, Bearden Shawn E
Northern Medical Program, University of Northern British Columbia, Prince George, British Columbia, Canada.
Microcirculation. 2006 Jun;13(4):275-7. doi: 10.1080/10739680600618710.
Microvascular structure and function are key aspects of tissue and organ health. At approximately 40% of total body mass, skeletal muscle contains more microvessels than any other organ system in the body. Moreover, skeletal muscle is the most dynamic tissue in the body with the capacity to increase blood flow and metabolic rate 30- to 50- fold. Aging is associated with decrements in microvascular function and exercise tolerance that are poorly understood. Here, experts in their respective fields of microvascular structure and function are brought together to review the current state of knowledge regarding microvascular adaptations to aging. Reviews are drawn from human and animal studies and focus on age-related changes in sympathetic nervous system control of microvessels, capillary hemodynamics and oxygen pressure, microvascular network structure and functional integration, microvascular reactivity, whole muscle perfusion, and cellular contacts and inflammation.
微血管结构和功能是组织和器官健康的关键方面。骨骼肌约占全身质量的40%，其微血管比身体其他任何器官系统都多。此外，骨骼肌是身体中最具活力的组织，能够将血流量和代谢率提高30至50倍。衰老与微血管功能减退和运动耐力下降有关，对此人们了解甚少。在这里，微血管结构和功能各自领域的专家齐聚一堂，回顾关于微血管对衰老适应的当前知识状态。综述来自人类和动物研究，重点关注交感神经系统对微血管控制、毛细血管血流动力学和氧压、微血管网络结构和功能整合、微血管反应性、全肌肉灌注以及细胞接触和炎症方面与年龄相关的变化。
