Theodore W H, Rose D, Patronas N, Sato S, Holmes M, Bairamian D, Porter R J, Di Chiro G, Larson S, Fishbein D
Ann Neurol. 1987 Jan;21(1):14-21. doi: 10.1002/ana.410210105.
We used positron emission tomography with fluorine 18-labeled 2-deoxyglucose to study cerebral glucose metabolism in 10 patients with Lennox-Gastaut syndrome who had normal neuroradiological studies. The scans showed decreased metabolic rates relative both to those in the caudate nucleus and to normal control values in 3 patients whose seizures began before the age of 1, as well as in a patient with hyperprolinemia. No patient had a region of persistent focal hypometabolism. Metabolic rates increased in parallel with increased electroencephalographic discharges in 1 patient; 3 patients had lower metabolic rates when the electroencephalogram showed epileptiform discharges and while the patients were taking barbiturates.
我们使用氟-18标记的2-脱氧葡萄糖正电子发射断层扫描技术，对10例神经放射学检查正常的Lennox-Gastaut综合征患者的脑葡萄糖代谢进行了研究。扫描结果显示，3例1岁前起病的患者以及1例高脯氨酸血症患者的代谢率相对于尾状核代谢率和正常对照值均降低。没有患者存在持续性局灶性代谢减低区域。1例患者的代谢率随脑电图放电增加而平行升高；3例患者在脑电图显示癫痫样放电且服用巴比妥类药物时，代谢率较低。
