Yanai K, Iinuma K, Matsuzawa T, Ito M, Miyabayashi S, Narisawa K, Ido T, Yamada K, Tada K
Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Eur J Nucl Med. 1987;13(6):292-6. doi: 10.1007/BF00256553.
We measured local cerebral glucose utilization in 19 patients with Lennox-Gastaut syndrome (LG), partial seizures (PS), atypical and classical phenylketonuria (PKU), Leigh disease, and subacute sclerosing panencephalitis (SSPE), using positron emission tomography (PET). The mean values of regional glucose utilization in interictal scans of LG were significantly reduced in all brain regions when compared with that of PS (P less than 0.005). PET studies of glucose utilization in LG revealed more widespread hypometabolism than in PS. Two siblings with dihydropteridine reductase deficiency, a patient with classical PKU, and a boy with cytochrome c oxidase deficiency showed reduced glucose utilization in the caudate and putamen. A marked decrease in glucose utilization was found in the cortical gray matter of a patient with rapidly progressive SSPE, despite relatively preserved utilization in the caudate and putamen. The PET study of a patient with slowly progressive SSPE revealed patterns and values of glucose utilization similar to those of the control. Thus, PET provided a useful clue toward understanding brain dysfunction in LG, PS, PKU, Leigh disease, and SSPE.
我们使用正电子发射断层扫描（PET）对19例患有伦诺克斯 - 加斯托综合征（LG）、部分性癫痫（PS）、非典型和经典苯丙酮尿症（PKU）、 Leigh病以及亚急性硬化性全脑炎（SSPE）的患者进行了局部脑葡萄糖利用情况的测量。与PS患者相比，LG患者发作间期扫描中所有脑区的区域葡萄糖利用平均值均显著降低（P小于0.005）。LG患者葡萄糖利用情况的PET研究显示，其代谢减退比PS患者更为广泛。两名患有二氢蝶啶还原酶缺乏症的同胞、一名经典PKU患者以及一名患有细胞色素c氧化酶缺乏症的男孩，其尾状核和壳核的葡萄糖利用均降低。一名快速进展型SSPE患者的皮质灰质葡萄糖利用显著降低，尽管其尾状核和壳核的利用相对保留。一名缓慢进展型SSPE患者的PET研究显示，其葡萄糖利用模式和数值与对照组相似。因此，PET为理解LG、PS、PKU、Leigh病和SSPE中的脑功能障碍提供了有用线索。
