Šalamon Špela, Kramar Barbara, Marolt Tinkara Pirc, Poljšak Borut, Milisav Irina
Center for human molecular genetics and pharmacogenomics, Faculty of Medicine, University of Maribor, SI-2000 Maribor, Slovenia.
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.
Antioxidants (Basel). 2019 Apr 28;8(5):111. doi: 10.3390/antiox8050111.
N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings. There are numerous other uses or proposed uses in medicine that are still in preclinical and clinical investigations. NAC is also used in food supplements and cosmetics. Despite its abundant use, there are projections that the NAC global market will grow in the next five years; therefore, the purpose of this work is to provide a balanced view of further uses of NAC as a dietary supplement. Although NAC is considered a safe substance, the results among clinical trials are sometimes controversial or incomplete, like for many other antioxidants. More clinical trials are underway that will improve our understanding of NAC applicability.
N-乙酰半胱氨酸（NAC）是一种天然存在于洋葱中的植物抗氧化剂，是谷胱甘肽的前体。自20世纪60年代以来，它一直被用作药物，并被列入世界卫生组织（WHO）基本药物示范清单，作为中毒的解毒剂。在医学上还有许多其他用途或拟议用途仍处于临床前和临床研究阶段。NAC也用于食品补充剂和化妆品。尽管其使用广泛，但预计未来五年NAC全球市场仍将增长；因此，这项工作的目的是对NAC作为膳食补充剂的进一步用途提供一个全面的看法。尽管NAC被认为是一种安全的物质，但临床试验的结果有时存在争议或不完整，许多其他抗氧化剂也是如此。更多的临床试验正在进行中，这将增进我们对NAC适用性的理解。
