Senghore Thomas, Wang Wen-Chang, Chien Huei-Tzu, Chen You-Xin, Young Chi-Kuang, Huang Shiang-Fu, Yeh Chih-Ching
Department of Public Health, School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan.
Department of Nursing, School of Medicine and Allied Health Sciences, University of The Gambia, Independence Drive, Banjul, P. O. Box 1646, The Gambia.
Cancers (Basel). 2019 Apr 29;11(5):598. doi: 10.3390/cancers11050598.
We aimed to investigate the association between single-nucleotide polymorphisms (SNP) in mismatch repair (MMR) pathway genes and survival in patients with oral squamous cell carcinoma (OSCC) who received adjuvant concurrent chemoradiotherapy (CCRT).
Using the Sequenom iPLEX MassARRAY system, five SNPs in four major MMR genes were genotyped in 319 patients with OSCC who received CCRT treatment. Kaplan-Meier survival curves and Cox proportional hazard regression models were used to assess overall survival (OS) and disease-free survival (DFS) among MMR genotypes.
The results of Kaplan-Meier survival analysis revealed that the MutS homolog 2 rs3732183 polymorphism showed a borderline significant association with DFS (log-rank = 0.089). Participants with the rs3732183 GG genotype exhibited a relatively low risk of recurrence (hazard ratio (HR) = 0.45; 95% confidence interval (CI) = 0.22-0.96; = 0.039). In addition, the MutL homolog 1 ( rs1800734 GG genotype carriers exhibited higher OS (HR = 0.52, 95% CI = 0.27-1.01; = 0.054) and DFS (HR = 0.49, 95% CI = 0.26-0.92; = 0.028) rates.
Our results indicated that the GG genotypes of rs3732183 and rs1800734 are associated with relatively high survival in OSCC patients treated using adjuvant CCRT. These polymorphisms may serve as prognosis predictors in OSCC patients.
我们旨在研究错配修复（MMR）通路基因中的单核苷酸多态性（SNP）与接受辅助同步放化疗（CCRT）的口腔鳞状细胞癌（OSCC）患者生存率之间的关联。
使用Sequenom iPLEX MassARRAY系统，对319例接受CCRT治疗的OSCC患者的四个主要MMR基因中的五个SNP进行基因分型。采用Kaplan-Meier生存曲线和Cox比例风险回归模型评估MMR基因分型中的总生存期（OS）和无病生存期（DFS）。
Kaplan-Meier生存分析结果显示，MutS同源物2 rs3732183多态性与DFS有边缘显著关联（对数秩=0.089）。rs3732183 GG基因型参与者的复发风险相对较低（风险比（HR）=0.45；95%置信区间（CI）=0.22-0.96；P=0.039）。此外，MutL同源物1（rs1800734）GG基因型携带者的OS（HR=0.52，95%CI=0.27-1.01；P=0.054）和DFS（HR=0.49，95%CI=0.26-0.92；P=0.028）率较高。
我们的结果表明，rs3732183和rs1800734的GG基因型与接受辅助CCRT治疗的OSCC患者的相对高生存率相关。这些多态性可能作为OSCC患者的预后预测指标。
