Laboratório de Gastroenterologia Clínica e Experimental (LIM-07) do Departamento de Gastroenterologia e Hepatologia do Hospital das Clínicas HCFMUSP da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil; Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Laboratório de Gastroenterologia Clínica e Experimental (LIM-07) do Departamento de Gastroenterologia e Hepatologia do Hospital das Clínicas HCFMUSP da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Ann Hepatol. 2019 May-Jun;18(3):416-421. doi: 10.1016/j.aohep.2019.04.006. Epub 2019 Apr 16.
Genetic predisposition, the intestinal microbiota (IM) and environmental factors, such as sedentary lifestyle and inadequate diet, should be considered as critical factors for the development of nonalcoholic fatty liver disease (NAFLD). Recently, some studies have demonstrated an association between dysbiosis and NAFLD; however, the exact mechanisms that lead to intestinal membrane damage, bacterial translocation and inflammation are not well elucidated. Due to the relevance of this theme, the IM and its metabolites have received special attention in recent years in an attempt to better understand the mechanisms related to the prevention, physiopathology, and treatment of NAFLD. In this paper, we provide a review of the human IM and its role in diet, obesity, and the development/progression of NAFLD/NASH, as well as the use of prebiotics and probiotics in the modulation of IM.
遗传易感性、肠道微生物群（IM）和环境因素，如久坐的生活方式和饮食不当，应被视为非酒精性脂肪性肝病（NAFLD）发展的关键因素。最近的一些研究表明，肠道菌群失调与 NAFLD 之间存在关联；然而，导致肠黏膜损伤、细菌易位和炎症的确切机制尚不清楚。由于这个主题的相关性，IM 及其代谢物近年来受到了特别关注，试图更好地理解与 NAFLD/NASH 的预防、病理生理学和治疗相关的机制。在本文中，我们综述了人类 IM 及其在饮食、肥胖和 NAFLD/NASH 的发生/进展中的作用，以及使用益生元和益生菌来调节 IM。
