接受直接抗病毒药物治疗的丙型肝炎患者中疱疹病毒的再激活
Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents.
作者信息
Ghweil Ali A, Helal Mohamad M
机构信息
Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt,
出版信息
Infect Drug Resist. 2019 Apr 2;12:759-762. doi: 10.2147/IDR.S184598. eCollection 2019.
Abstract
BACKGROUND
We performed a case-series analysis of reactivation of herpesvirus in patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents.
METHODS
Eight cases were detected among 100 treated patients with DAA regimens in Qena University Hospital from June 2016 to June 2017. Herpesvirus was reactivated in eight patients who received DAA therapy. None of the cases had risk factor for herpes zoster reactivation.
RESULTS
The DAA regimens used were sofosbuvir/daclatasvir in six cases and sofosbuvir/ledipasvir in two cases. Immune changes that follow HCV clearance might lead to reactivation of other viruses, such as herpesvirus.
CONCLUSION
Patients with HCV infection suspected of having herpesvirus infection should be treated promptly.
摘要
背景
我们对接受直接抗病毒药物（DAA）治疗的丙型肝炎病毒（HCV）感染患者的疱疹病毒再激活情况进行了病例系列分析。
方法
2016年6月至2017年6月期间，在基纳大学医院接受DAA方案治疗的100例患者中检测到8例。接受DAA治疗的8例患者中疱疹病毒再激活。所有病例均无带状疱疹再激活的危险因素。
结果
使用的DAA方案中，6例为索磷布韦/达卡他韦，2例为索磷布韦/来迪帕司韦。HCV清除后随之发生的免疫变化可能导致其他病毒如疱疹病毒的再激活。
结论
怀疑有疱疹病毒感染的HCV感染患者应及时接受治疗。
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