Heydarian Farhad, Bakhtiari Elham, Badzaee Shima, Heidarian Mohammad
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Research Center for Patient Safety, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Child Neurol. 2019 Spring;13(2):47-52.
This study investigated the clinical characteristics and serum sodium level in children with gastroenteritis related seizure with or without fever.
MATERIALS & METHODS: This clinical study was performed in Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran from 2007 to 2014. Overall, 165 patients aged 6-60 months with gastroenteritis related seizure were studied. Demographic, seizure and gastroenteritis characteristics and laboratory findings were recorded.
Among the 165 children 47.3% were female. Vomiting was 2.7±2.6 and 3.9±1.9 times in febrile and afebrile group. Duration of diarrhea was 1.8±1.8 days and 2.1±1.3 days in febrile and afebrile groups (p=0.014). 36% in febrile group and 6.4% in afebrile group experienced seizure within the first 24 h of gastroenteritis (<0.001). Seizure in 99.1% in febrile and 93.6% in afebrile group was generalized (>0.05). Seizure was more than 5 min in 51.4% in febrile and 57.4% in afebrile groups (>0.05). Drowsiness after seizure was seen in 72.9% and 60% in febrile and afebrile group respectively (>0.05). The serum level of sodium was 137.6±3.98 mEq/L and 138.5±3.78 mEq/L in febrile and afebrile groups (>0.05). 26.3% in febrile group and 8.5% in afebrile group had hyponatremia (=0.012). There was no difference in seizure duration between hyponatremic patients and others (>0.05).
Type, duration of seizure and drowsiness after seizure had not any difference in febrile and afebrile cases. Vomiting and duration of diarrhea before admission was lower in febrile group. Seizure within the first 24 h of gastroenteritis was higher in febrile group. Mild hyponatremia in febrile group was higher than afebrile group. No difference in duration of seizure was detected between hyponatremic patients and others.
本研究调查了伴或不伴发热的肠胃炎相关性惊厥患儿的临床特征及血清钠水平。
本临床研究于2007年至2014年在伊朗马什哈德医科大学加姆医院进行。共研究了165例年龄在6至60个月的肠胃炎相关性惊厥患者。记录了人口统计学、惊厥和肠胃炎特征以及实验室检查结果。
165名儿童中47.3%为女性。发热组和非发热组的呕吐次数分别为2.7±2.6次和3.9±1.9次。发热组和非发热组的腹泻持续时间分别为1.8±1.8天和2.1±1.3天（p=0.014）。发热组36%和非发热组6.4%在肠胃炎的头24小时内发生惊厥（<0.001）。发热组99.1%和非发热组93.6%的惊厥为全身性（>0.05）。发热组51.4%和非发热组57.4%的惊厥持续超过5分钟（>0.05）。发热组和非发热组惊厥后嗜睡的发生率分别为72.9%和60%（>0.05）。发热组和非发热组的血清钠水平分别为137.6±3.98 mEq/L和138.5±3.78 mEq/L（>0.05）。发热组26.3%和非发热组8.5%有低钠血症（=0.012）。低钠血症患者与其他患者的惊厥持续时间无差异（>0.05）。
发热和非发热病例在惊厥类型、惊厥持续时间和惊厥后嗜睡方面无差异。发热组入院前的呕吐次数和腹泻持续时间较低。发热组在肠胃炎头24小时内发生惊厥的比例较高。发热组轻度低钠血症高于非发热组。低钠血症患者与其他患者的惊厥持续时间未检测到差异。
