Geisinger Autism & Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Suite 2A, Lewisburg, PA, 17837, USA.
Department of Biomedical & Translational Informatics, Geisinger, Geisinger Health System, 100 N Academy Ave, Danville, PA, 17822, USA.
J Autism Dev Disord. 2019 Jul;49(7):3016-3030. doi: 10.1007/s10803-019-04028-7.
We applied a trajectory-based analysis to eye tracking data in order to quantify individualized patterns of pupil response in the context of global-local processing that may be associated with autism spectrum disorder (ASD) features. Multiple pupil response trajectories across both global and local conditions were identified. Using the combined trajectory patterns for global and local conditions for each individual, we were able to identify three groups based on trajectory group membership that were thought to reflect perceptual strategy. Results indicated that the proportion of children with ASD was significantly greater in the group demonstrating a local-focus response. This research presents a novel analytic approach to the objective characterization of individualized pupil response patterns that are associated with ASD features.
我们应用轨迹分析方法对眼动追踪数据进行分析，以量化在全局-局部处理背景下与自闭症谱系障碍（ASD）特征相关的个体瞳孔反应模式。确定了在全局和局部条件下的多个瞳孔反应轨迹。使用每个人在全局和局部条件下的组合轨迹模式，我们能够根据轨迹组的成员身份识别出三个组，这些组被认为反映了感知策略。结果表明，表现出局部焦点反应的组中，患有 ASD 的儿童比例明显更高。这项研究提出了一种新颖的分析方法，用于客观描述与 ASD 特征相关的个体瞳孔反应模式。
