Geisinger Health System, Geisinger Autism & Developmental Medicine Institute (ADMI), 120 Hamm Drive, Suite 2A, Lewisburg, PA, 17837, USA.
Department of Biomedical & Translational Informatics, Geisinger, 100 N Academy Ave, Danville, PA, 17822, USA.
J Autism Dev Disord. 2019 Dec;49(12):5086-5099. doi: 10.1007/s10803-019-04213-8.
We assessed the association between dynamic changes in pupil response in the context of visual perception and quantitative measures of the autism phenotype in healthy adults. Using Navon stimuli in a task-switching paradigm, participants were instructed to identify global or local information based on a cue. Multiple pupil response trajectories across conditions were identified. We combined trajectory patterns for global and local conditions and used data-driven methods to identify three distinct pupil trajectory sub-groups. We report higher scores on quantitative measures of autism features in individuals who demonstrated an increased change in pupil diameter across both conditions. Results demonstrate the use of individualized pupil response trajectories in order to quantitatively characterize visual perception associated with the broader autism phenotype (BAP).
我们评估了在健康成年人的视觉感知背景下，瞳孔反应的动态变化与自闭症表型的定量测量之间的关联。使用任务转换范式中的纳冯刺激，参与者根据提示来识别全局或局部信息。在多种条件下确定了多个瞳孔反应轨迹。我们将全局和局部条件的轨迹模式结合起来，并使用数据驱动的方法来识别三个不同的瞳孔轨迹子组。我们报告了在两种条件下瞳孔直径变化较大的个体在自闭症特征定量测量上的得分更高。研究结果表明，可以使用个性化的瞳孔反应轨迹来定量描述与广泛自闭症表型（BAP）相关的视觉感知。
