International Frontier, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan.
School of Dentistry, Showa University, Tokyo, Japan.
Adv Exp Med Biol. 2019;1132:7-20. doi: 10.1007/978-981-13-6657-4_2.
Although many studies have described the role of periostin in various diseases, the functions of periostin derived from alternative splicing and proteinase cleavage at its C-terminus remain unknown. Further experiments investigating the periostin structures that are relevant to diseases are essential for an in-depth understanding of their functions, which would accelerate their clinical applications by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress .
虽然许多研究已经描述了外骨蛋白在各种疾病中的作用，但其 C 末端的选择性剪接和蛋白酶切割衍生的功能仍然未知。进一步研究与疾病相关的外骨蛋白结构对于深入了解其功能至关重要，这将通过建立治疗难治性疾病的新方法来加速其临床应用。此外，这一理解将增强我们对与干性和机械应激反应相关的外骨蛋白新功能的认识。
