Yoshihara Tomohito, Morimoto Tadatsugu, Hirata Hirohito, Murayama Masatoshi, Nonaka Toshihiro, Tsukamoto Masatsugu, Toda Yu, Kobayashi Takaomi, Izuhara Kenji, Mawatari Masaaki
Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan.
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
Front Med (Lausanne). 2023 Oct 31;10:1276900. doi: 10.3389/fmed.2023.1276900. eCollection 2023.
Periostin (POSTN) serves a dual role as both a matricellular protein and an extracellular matrix (ECM) protein and is widely expressed in various tissues and cells. As an ECM protein, POSTN binds to integrin receptors, transduces signals to cells, enabling cell activation. POSTN has been linked with various diseases, including atopic dermatitis, asthma, and the progression of multiple cancers. Recently, its association with orthopedic diseases, such as osteoporosis, osteoarthritis resulting from cartilage destruction, degenerative diseases of the intervertebral disks, and ligament degenerative diseases, has also become apparent. Furthermore, POSTN has been shown to be a valuable biomarker for understanding the pathophysiology of orthopedic diseases. In addition to serum POSTN, synovial fluid POSTN in joints has been reported to be useful as a biomarker. Risk factors for spinal degenerative diseases include aging, mechanical stress, trauma, genetic predisposition, obesity, and metabolic syndrome, but the cause of spinal degenerative diseases (SDDs) remains unclear. Studies on the pathophysiological effects of POSTN may significantly contribute toward the diagnosis and treatment of spinal degenerative diseases. Therefore, in this review, we aim to examine the mechanisms of tissue degeneration caused by mechanical and inflammatory stresses in the bones, cartilage, intervertebral disks, and ligaments, which are crucial components of the spine, with a focus on POSTN.
骨膜蛋白（POSTN）作为一种基质细胞蛋白和细胞外基质（ECM）蛋白发挥双重作用，在各种组织和细胞中广泛表达。作为一种ECM蛋白，POSTN与整合素受体结合，向细胞传导信号，从而激活细胞。POSTN与多种疾病有关，包括特应性皮炎、哮喘以及多种癌症的进展。最近，它与骨科疾病的关联也变得明显，如骨质疏松症、软骨破坏导致的骨关节炎、椎间盘退行性疾病以及韧带退行性疾病。此外，POSTN已被证明是理解骨科疾病病理生理学的一个有价值的生物标志物。除了血清POSTN外，关节滑液中的POSTN也被报道可用作生物标志物。脊柱退行性疾病的危险因素包括衰老、机械应力、创伤、遗传易感性、肥胖和代谢综合征，但脊柱退行性疾病（SDD）的病因仍不清楚。对POSTN病理生理作用的研究可能对脊柱退行性疾病的诊断和治疗有重大贡献。因此，在本综述中，我们旨在研究由机械和炎症应力引起的骨骼、软骨、椎间盘和韧带组织退变的机制，这些是脊柱的关键组成部分，重点是POSTN。
