Preslock J P, McCann S M
Brain Res Bull. 1987 Jan;18(1):127-34. doi: 10.1016/0361-9230(87)90041-4.
Bilateral lesions were placed in the sexually dimorphic nucleus of the preoptic area (SDN-POA) in castrated adult male rats in an attempt to determine a physiologic role for this nucleus. These lesions significantly attenuated the increase in plasma FSH and LH due to simultaneous castration at 24 hr, and at 7 and 14 days following surgery, and significantly decreased the levels of plasma prolactin on comparison with pre-operative values and those of castrated controls. When rats were castrated and lesions placed at 14 days following castration, plasma levels of FSH, LH and prolactin were significantly decreased at 24 hr and at 7 days following surgery. Lesions which were placed lateral or caudal to the SDN-POA simulated the effects of lesions placed within the SDN-POA upon plasma LH, FSH and prolactin, with lateral lesions being most effective. However, lesions which were placed dorsal or rostral to the SDN-POA had no effect. The results of these studies suggest that the SDN-POA may be involved in the regulation of LH, FSH, and prolactin release.
对成年去势雄性大鼠的视前区性二态核（SDN-POA）进行双侧损伤，以确定该核的生理作用。这些损伤显著减弱了因在术后24小时、7天和14天同时去势导致的血浆促卵泡激素（FSH）和促黄体生成素（LH）的升高，并且与术前值及去势对照组相比，显著降低了血浆催乳素水平。当大鼠在去势后14天进行去势及损伤时，术后24小时和7天血浆FSH、LH和催乳素水平显著降低。置于SDN-POA外侧或尾侧的损伤模拟了置于SDN-POA内的损伤对血浆LH、FSH和催乳素的影响，外侧损伤最为有效。然而，置于SDN-POA背侧或嘴侧的损伤则没有效果。这些研究结果表明，SDN-POA可能参与LH、FSH和催乳素释放的调节。
