Department of Neurology, Hospital of South West Jutland, Esbjerg, Denmark.
Research Unit of Health Science, Hospital of South West Jutland, Esbjerg, Denmark.
Acta Neurol Scand. 2019 Aug;140(2):116-122. doi: 10.1111/ane.13111. Epub 2019 May 15.
Medication-overuse headache (MOH) is recognized as a biobehavioural disorder, warranting that both biological and psychological factors are targeted throughout treatment. A psychological factor of importance may be personality that could be used to tailor treatment if differences are found across headache diagnoses. The objectives were as follows: (a) To investigate if migraine patients and patients with MOH differed on personality traits, (b) To investigate if the two headache groups differed from a Danish normative sample, with respect to personality traits.
The NEO-Five-Factor Inventory was completed, and an age-matched cohort of episodic migraine patients (n = 94) and MOH patients (n = 94) was included. Multivariate regression models and sex-stratified comparisons were made on patients' raw scores from five personality traits; neuroticism, extraversion, openness, agreeableness, and conscientiousness. The headache groups were also compared to personality traits from a Danish normative sample (n = 1032).
MOH females obtained significantly lower scores on extraversion (24.4 ± 4.3 vs 27.1 ± 7.2, P < 0.01), openness (23.7 ± 3.9 vs 26.2 ± 6.4, P < 0.01), and conscientiousness (28.9 ± 3.7 vs 34.6 ± 5.8, P > 0.01) as compared to female migraineurs. Males showed no differences. Compared to the normative sample, both headache groups showed a lower score on extraversion (P < 0.01). Furthermore, MOH patients had statistically significant lower scores on conscientiousness while the migraine patients had a higher score.
Results suggests some personality trait differences between migraine and MOH patients. Especially, females showed different personality traits, where the MOH females appeared more introvert and less socially orientated. If confirmed in larger studies, this information could be used in personalized treatment in clinical practice.
药物过度使用性头痛（MOH）被认为是一种生物行为障碍，这表明在治疗过程中应同时针对生物学和心理学因素。一个重要的心理因素可能是人格，如果在不同的头痛诊断中发现差异，那么人格可以用于定制治疗。目的如下：（a）调查偏头痛患者和 MOH 患者在人格特质上是否存在差异，（b）调查这两个头痛组在人格特质方面是否与丹麦的正常样本不同。
完成 NEO 五因素量表（NEO-Five-Factor Inventory），纳入了一个年龄匹配的发作性偏头痛患者队列（n=94）和 MOH 患者队列（n=94）。对五个人格特质的原始分数进行了多变量回归模型和性别分层比较；神经质、外向性、开放性、宜人性和尽责性。头痛组还与丹麦正常样本的人格特质进行了比较（n=1032）。
MOH 女性在外向性（24.4±4.3 与 27.1±7.2，P<0.01）、开放性（23.7±3.9 与 26.2±6.4，P<0.01）和尽责性（28.9±3.7 与 34.6±5.8，P>0.01）方面的得分明显低于偏头痛女性。男性没有差异。与正常样本相比，两个头痛组的外向性得分均较低（P<0.01）。此外，MOH 患者的尽责性得分显著较低，而偏头痛患者的得分较高。
结果表明偏头痛和 MOH 患者之间存在一些人格特质差异。特别是女性表现出不同的人格特质，MOH 女性表现出更内向和较少社交倾向。如果在更大的研究中得到证实，这些信息可以在临床实践中用于个性化治疗。
