Department of Pneumology and Allergy, World Association for Sarcoidosis and Other Granulomatous Disorders (WASOG) Recognized Sarcoidosis Clinic, Medical University of Lodz, Kopcińskiego 22, 90-153, Lodz, Poland.
Department of Pathobiology of Respiratory Diseases, Medical University of Lodz, Lodz, Poland.
Sci Rep. 2021 May 13;11(1):10242. doi: 10.1038/s41598-021-89383-1.
Sarcoidosis is granulomatous disease, which complex etiology is yet to be fully discovered. In the majority of cases its course is self-limiting. However it can have different clinical manifestations and can be debilitating condition with great impact on health-related quality of life (HRQL). The aim of our study was to assess if there are any differences in HRQL dependent to gender. We examined a group of 33 males and 42 females (with no differences in mean age, disease activity, TLCO, FEV, FVC, FEV/FVC) with a use of Sarcoidosis Health Questionnaire. We revealed lower total and daily functioning score in female group. Further analyses stratified by sex and activity of the disease presented many significant differences between the groups, revealing important issues for the discussion about gender specific differences in the HRQL of patients with sarcoidosis. In spite of clinical presentation may be similar, expectations and main concerns of sarcoidosis patient can vary between females and males. Therefore, it appears that in terms of education and symptomatic treatment accents should be put differently depending on the gender of the patient. Our results may also point to a need for more gender-oriented patient-physician communication which could enable better understanding, potentially improve adherence to therapy and decrease the risk of possible complications.
结节病是一种肉芽肿性疾病,其复杂的病因尚未完全发现。在大多数情况下,其病程是自限性的。然而,它可能有不同的临床表现,并可能导致身体虚弱,对健康相关生活质量(HRQL)有很大影响。我们的研究目的是评估性别是否会对 HRQL 产生影响。我们检查了一组 33 名男性和 42 名女性(平均年龄、疾病活动度、TLCO、FEV、FVC、FEV/FVC 无差异),使用了结节病健康问卷。我们发现女性组的总功能和日常功能评分较低。进一步按性别和疾病活动度进行分层分析,两组之间存在许多显著差异,揭示了关于结节病患者 HRQL 中性别差异的重要问题。尽管临床表现可能相似,但结节病患者的期望和主要关注点在女性和男性之间可能有所不同。因此,在教育和对症治疗方面,根据患者的性别,应该有不同的侧重点。我们的研究结果也可能表明需要进行更多面向性别的医患沟通,这可以使医患双方更好地理解,潜在地提高治疗的依从性,并降低潜在并发症的风险。