International Renal Research Institute of Vicenza, Vicenza, Italy,
Department of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy,
Blood Purif. 2019;48(1):18-24. doi: 10.1159/000499076. Epub 2019 Apr 30.
Recent innovations in biomaterials technology have led to the development of innovative sorbents adopted as adsorbing devices in the field of extracorporeal blood purification therapies. As removal mechanism, adsorption allows to remove specific molecules, selectively binding them to sorbent materials. In addition to the material properties, a quintessential aspect influencing device properties is blood flow distribution within the sorbent particles.
In order to adequately characterize the potential adsorbing properties for an effective blood purification therapy, an in vitro study assessing the fluid dynamics inside 3 new cartridges, HA130, HA230 and HA330 (Jafron, Zhuhai City, -China) was conducted through CT imaging technique. -Methods: The cartridges were placed in vertical position in the CT -gantry. Dye solution was circulated through the cartridges at 250 mL/min, longitudinal sections, 0.5 cm thick, were recorded for 60 s. Furthermore, an in vitro test was conducted to build pressure drop profiles. Blood was circulated at a different flow rate, 100-400 mL/min, step 50 mL/min. Pre and post cartridges pressures were acquired and pressure drop calculated.
Sequential images demonstrated an excellent distribution of the flow inside the cartridges. Average flow velocity was 0.37 cm/s for the 3 cartridges. HA130 had a homogeneous flow profile along the entire length of the device; HA230 and HA330 showed minimal differences between central and peripheral regions. Pressure drop profiles resulted linear, increasing proportionally with blood flow rate and packing density.
We may conclude that the structural and functional design of the studied cartridges is adequate for haemoperfusion with no channelling phenomena. This ensures maximum and optimal utilization of the sorbent contained in the devices.
生物材料技术的最新创新导致了创新吸附剂的发展，这些吸附剂被采用作为体外血液净化治疗领域的吸附装置。作为去除机制，吸附允许选择性地将特定分子结合到吸附材料上，从而去除它们。除了材料特性外，影响装置特性的一个重要方面是血液在吸附剂颗粒内的流动分布。
为了充分表征有效血液净化治疗的潜在吸附特性，通过 CT 成像技术对 3 种新型 HA130、HA230 和 HA330 （珠海捷创生物科技有限公司，中国）进行了体外研究，评估了 3 种新的吸附柱内部的流体动力学。
将吸附柱置于 CT 机的垂直位置。将染料溶液以 250mL/min 的速度循环通过吸附柱，记录 60 秒的 0.5cm 厚的纵向切片。此外，还进行了体外测试以构建压降曲线。血液以 100-400mL/min 的不同流速循环，每次增加 50mL/min。采集吸附柱前后的压力，并计算压降。
连续的图像显示出了吸附柱内流动的良好分布。3 种吸附柱的平均流速均为 0.37cm/s。HA130 整个装置的流速分布均匀；HA230 和 HA330 中央区域和周边区域的流速差异最小。压降曲线呈线性，随血液流速和填充密度的增加而线性增加。
可以得出结论，研究中吸附柱的结构和功能设计适用于无通道现象的血液灌流。这确保了装置中所含吸附剂的最大和最佳利用。
