• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肾脏近端小管中的血管紧张素 III/AT 受体/NHE3 信号通路：高血压中的一种新型利钠和降压机制。

Angiotensin III/AT Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension.

机构信息

1 Laboratory of Receptor and Signal Transduction Department of Pharmacology and Toxicology University of Mississippi Medical Center Jackson MS.

2 Division of Nephrology Department of Medicine University of Mississippi Medical Center Jackson MS.

出版信息

J Am Heart Assoc. 2019 May 7;8(9):e012644. doi: 10.1161/JAHA.119.012644.

DOI:10.1161/JAHA.119.012644
PMID:31039655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6512110/
Abstract

See Article Kemp et al.

摘要

参见 Kemp 等人的文章。

相似文献

1
Angiotensin III/AT Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension.肾脏近端小管中的血管紧张素 III/AT 受体/NHE3 信号通路：高血压中的一种新型利钠和降压机制。
J Am Heart Assoc. 2019 May 7;8(9):e012644. doi: 10.1161/JAHA.119.012644.
2
Proximal Tubule-Specific Deletion of the NHE3 (Na/H Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.肾脏近端小管特异性敲除 NHE3（钠/氢交换器 3）可减轻血管紧张素 II（Angiotensin II）诱导的小鼠高血压。
Hypertension. 2019 Sep;74(3):526-535. doi: 10.1161/HYPERTENSIONAHA.119.13094. Epub 2019 Jul 29.
3
Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells.血管紧张素II可抵消cAMP/PKA对近端小管细胞中NHE3活性和磷酸化的作用。
Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C768-C776. doi: 10.1152/ajpcell.00191.2016. Epub 2016 Aug 10.
4
Defective Renal Angiotensin III and AT Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats.原发性高血压大鼠肾血管紧张素 III 和 AT 受体信号缺陷与高血压前期
J Am Heart Assoc. 2019 May 7;8(9):e012016. doi: 10.1161/JAHA.119.012016.
5
Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension.急性和慢性高血压诱导近端小管中钠氢交换体亚型NHE3的重新分布。
Am J Physiol. 1998 Oct;275(4):F565-75. doi: 10.1152/ajprenal.1998.275.4.F565.
6
New Insights into the Critical Importance of Intratubular Na/H Exchanger 3 and Its Potential Therapeutic Implications in Hypertension.管腔内 Na/H 交换器 3 的关键重要性的新见解及其在高血压中的潜在治疗意义。
Curr Hypertens Rep. 2021 Jun 10;23(6):34. doi: 10.1007/s11906-021-01152-7.
7
The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca] in the proximal tubules of spontaneously hypertensive rats.血管紧张素 -（1 - 7）对自发性高血压大鼠近端小管中交换体NHE3及[Ca]的影响。
Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F450-F460. doi: 10.1152/ajprenal.00557.2016. Epub 2017 May 10.
8
Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress.血管紧张素 II 介导电切双相调节近端肾小管钠/氢交换器 3 在氧化应激过程中受损。
Am J Physiol Renal Physiol. 2011 Aug;301(2):F364-70. doi: 10.1152/ajprenal.00121.2011. Epub 2011 May 18.
9
Proximal tubule Na transporter responses are the same during acute and chronic hypertension.在急性和慢性高血压期间，近端小管钠转运体反应是相同的。
Am J Physiol Renal Physiol. 2000 Aug;279(2):F358-69. doi: 10.1152/ajprenal.2000.279.2.F358.
10
AT2 Receptors: Potential Therapeutic Targets for Hypertension.血管紧张素Ⅱ2型受体：高血压的潜在治疗靶点
Am J Hypertens. 2017 Apr 1;30(4):339-347. doi: 10.1093/ajh/hpw121.

引用本文的文献

1
Herbal medicine (Oryeongsan) for fluid and sodium balance in renal cortex of spontaneously hypertensive rats.草药（五苓散）对自发性高血压大鼠肾皮质液体和钠平衡的影响
Integr Med Res. 2024 Mar;13(1):101007. doi: 10.1016/j.imr.2023.101007. Epub 2023 Nov 15.
2
Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases.肾素-血管紧张素-醛固酮系统中的性别差异及其在高血压、心血管疾病和肾脏疾病中的作用。
Front Cardiovasc Med. 2023 Jun 19;10:1198090. doi: 10.3389/fcvm.2023.1198090. eCollection 2023.
3
Alterations in Renin-Angiotensin System (RAS) Peptide Levels in Patients with HIV.人类免疫缺陷病毒（HIV）患者肾素-血管紧张素系统（RAS）肽水平的改变
Metabolites. 2022 Dec 31;13(1):61. doi: 10.3390/metabo13010061.
4
The Na/H Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension.肠道和肾脏近端小管中的钠/氢交换体3：定位、生理功能及在血管紧张素II诱导的高血压中的关键作用
Front Physiol. 2022 Apr 19;13:861659. doi: 10.3389/fphys.2022.861659. eCollection 2022.
5
Unraveling the Differentially Articulated Axes of the Century-Old Renin-Angiotensin-Aldosterone System: Potential Therapeutic Implications.解析百年历史的肾素-血管紧张素-醛固酮系统的差异化表达轴：潜在的治疗意义。
Cardiovasc Toxicol. 2022 Mar;22(3):246-253. doi: 10.1007/s12012-022-09724-y. Epub 2022 Feb 10.
6
The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.冠心病患者循环血管紧张素Ⅲ水平及其意义。
J Renin Angiotensin Aldosterone Syst. 2021 Sep 21;2021:1704762. doi: 10.1155/2021/1704762. eCollection 2021.
7
Circadian Control of Sodium and Blood Pressure Regulation.昼夜节律对钠和血压调节的控制。
Am J Hypertens. 2021 Nov 20;34(11):1130-1142. doi: 10.1093/ajh/hpab100.
8
Angiotensin II Type 2 Receptor: A Target for Protection Against Hypertension, Metabolic Dysfunction, and Organ Remodeling.血管紧张素II 2型受体：预防高血压、代谢功能障碍和器官重塑的靶点
Hypertension. 2021 Jun;77(6):1845-1856. doi: 10.1161/HYPERTENSIONAHA.120.11941. Epub 2021 Apr 12.
9
Identification of a Primary Renal AT Receptor Defect in Spontaneously Hypertensive Rats.原发性高血压大鼠肾血管紧张素 AT 受体缺陷的鉴定。
Circ Res. 2020 Feb 28;126(5):644-659. doi: 10.1161/CIRCRESAHA.119.316193. Epub 2020 Jan 30.

本文引用的文献

1
Defective Renal Angiotensin III and AT Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats.原发性高血压大鼠肾血管紧张素 III 和 AT 受体信号缺陷与高血压前期
J Am Heart Assoc. 2019 May 7;8(9):e012016. doi: 10.1161/JAHA.119.012016.
2
Genetic and genomic evidence for an important role of the Na/H exchanger 3 in blood pressure regulation and angiotensin II-induced hypertension.遗传和基因组证据表明，钠/氢交换器 3 在血压调节和血管紧张素 II 诱导的高血压中起着重要作用。
Physiol Genomics. 2019 Apr 1;51(4):97-108. doi: 10.1152/physiolgenomics.00122.2018. Epub 2019 Mar 8.
3
Proximal Tubule-Specific Deletion of the NHE3 (Na/H Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice.近端肾小管特异性敲除 NHE3（钠/氢交换器 3）可促进压力性利钠反应并降低小鼠血压。
Hypertension. 2018 Dec;72(6):1328-1336. doi: 10.1161/HYPERTENSIONAHA.118.10884.
4
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2017美国心脏病学会/美国心脏协会/美国医师助理学会/美国心脏病学学会/美国预防医学学院/美国老年病学会/美国药剂师协会/美国血液学会/美国预防心脏病学会/美国国家医学协会/美国初级保健医师学会成人高血压预防、检测、评估和管理指南：执行摘要：美国心脏病学会/美国心脏协会临床实践指南工作组报告
Circulation. 2018 Oct 23;138(17):e426-e483. doi: 10.1161/CIR.0000000000000597.
5
Intratubular and intracellular renin-angiotensin system in the kidney: a unifying perspective in blood pressure control.肾脏内管腔内和细胞内的肾素-血管紧张素系统：血压控制的统一观点。
Clin Sci (Lond). 2018 Jul 9;132(13):1383-1401. doi: 10.1042/CS20180121. Print 2018 Jul 16.
6
The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).肾素-血管紧张素系统的 ACE2/血管紧张素-(1-7)/MAS 轴：关注血管紧张素-(1-7)。
Physiol Rev. 2018 Jan 1;98(1):505-553. doi: 10.1152/physrev.00023.2016.
7
The prorenin receptor in the cardiovascular system and beyond.心血管系统及其他系统中的原肾素受体。
Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H139-H145. doi: 10.1152/ajpheart.00373.2017. Epub 2017 Nov 3.
8
The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases.肾素-血管紧张素系统的血管保护轴：心血管、高血压和肾脏疾病中的生理相关性和治疗意义。
Pharmacol Res. 2017 Nov;125(Pt A):21-38. doi: 10.1016/j.phrs.2017.06.005. Epub 2017 Jun 12.
9
Collecting duct (pro)renin receptor targets ENaC to mediate angiotensin II-induced hypertension.集合管（前）肾素受体靶向上皮钠通道以介导血管紧张素II诱导的高血压。
Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F245-F253. doi: 10.1152/ajprenal.00178.2016. Epub 2016 Apr 27.
10
Intrarenal Renin-Angiotensin System: Locally Synthesized or Taken up Via Endocytosis?肾内肾素-血管紧张素系统：是局部合成还是通过内吞作用摄取？
Hypertension. 2016 May;67(5):831-3. doi: 10.1161/HYPERTENSIONAHA.116.07103. Epub 2016 Feb 29.