冠心病患者循环血管紧张素Ⅲ水平及其意义。
The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.
机构信息
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Fine Arts School of Shandong University, Jinan, Shandong 250012, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2021 Sep 21;2021:1704762. doi: 10.1155/2021/1704762. eCollection 2021.
OBJECTIVE
Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).
METHODS AND RESULTS
Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls ( = 0.013). APA levels were slightly lower in the CAS group ( = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.
CONCLUSIONS
Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.
目的
血管紧张素-III（Ang-III）是血管紧张素-II（Ang-II）经氨基肽酶 A（APA）代谢的下游产物。目前，Ang-III 的研究主要集中在高血压和中枢肾素-血管紧张素系统（RAS）上。然而，很少有研究关注 Ang-III 与冠状动脉粥样硬化（CAS）之间的关系。
方法和结果
通过酶联免疫吸附试验（ELISA）测量 44 名正常受试者和 84 名经冠状动脉造影证实患有 CAS 的患者的血浆 Ang-III 和 APA 水平。与正常对照组相比，CAS 患者的循环 Ang-III 水平显著降低（ = 0.013）。CAS 组的 APA 水平略低（ = 0.324）。根据动脉粥样硬化的严重程度，将 CAS 患者分为两组。与对照组相比，高评分组的 APA 和 Ang-III 水平较低，且 APA 显著降低。
结论
CAS 患者的循环 Ang-III 水平降低，其可能的原因与 APA 水平降低有关。
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