Driver C J, Wallis R, Cosopodiotis G, Ettershank G
Exp Gerontol. 1986;21(6):497-507. doi: 10.1016/0531-5565(86)90002-1.
Previous work with a high fat/low carbohydrate diet indicated that Drosophila melanogaster aged faster on that diet than on a high carbohydrate/low fat diet. This could be due to one of eight possibilities enumerated. Oxygen consumption of flies on the high fat/low carbohydrate diet is initially the same as that on the control diet. Subsequently the oxygen consumption falls to below control levels at older ages. No increased rate of living is indicated. A starvation resistant strain is described. The male eats less food, and yet maintains a body fat level indistinguishable from the parent strain. The lifespan and most physiological indices of aging used indicate that the process of aging is unchanged. Nutrient dilution produces a nearly compensatory increase in food intake with a reduced body fat and body energy reserves. The indices of aging used indicate that the rate of aging is reduced under these circumstances. These results are consistent with the possibility that fat or a fat metabolite alters the rate of aging. It is argued from previous data that body fat itself is not likely to be the important factor, rather a metabolite is probably involved.
先前关于高脂肪/低碳水化合物饮食的研究表明，黑腹果蝇在这种饮食条件下比在高碳水化合物/低脂肪饮食条件下衰老得更快。这可能是由于所列举的八种可能性之一。高脂肪/低碳水化合物饮食果蝇的耗氧量最初与对照饮食果蝇相同。随后，在果蝇老年时耗氧量降至对照水平以下。未显示出生活速率增加。描述了一个抗饥饿品系。雄性果蝇进食较少食物，但仍维持与亲本品系难以区分的体脂水平。所使用的寿命和大多数衰老生理指标表明衰老过程未改变。营养稀释导致食物摄入量几乎补偿性增加，同时体脂和身体能量储备减少。所使用的衰老指标表明在这些情况下衰老速率降低。这些结果与脂肪或脂肪代谢物改变衰老速率的可能性一致。根据先前的数据推断，体脂本身不太可能是重要因素，可能涉及一种代谢物。
