高脂肪喂养期对人体碳水化合物平衡和随意能量摄入的影响。

Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans.

机构信息

Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

出版信息

Int J Obes (Lond). 2010 May;34(5):886-91. doi: 10.1038/ijo.2010.16. Epub 2010 Mar 2.

DOI:10.1038/ijo.2010.16

PMID:20195283

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4381993/

Abstract

OBJECTIVE

A reduction in glycogen after the switch to an isoenergetic high-fat diet (HFD) might promote a compensatory increase in food intake to reestablish carbohydrate balance. We assessed the effect of an isoenergetic switch from a 49%-carbohydrate to 50%-fat diet on nutrient balance and ad libitum food intake. We hypothesized that carbohydrate balance would be inversely related to ad libitum energy intake.

METHODS

In 47 men and 11 women (22.6+/-0.4 years; 26.1+/-0.5 kg m(-2)), fuel balance was measured in a respiration chamber over 4 days. During the first day, an isoenergetic, high-carbohydrate diet was provided followed by a 3-day isoenergetic, HFD. At the end of this period and after 16 h of fasting, three options of foods (cookies, fruit salad and turkey sandwich) were offered ad libitum for 4 h. The relationships between post-chamber ad libitum intake and macronutrient oxidation and balance measured day-to-day and over the 4-day respiration chamber stay were studied.

RESULTS

After switching to a HFD, 24-h respiratory quotient decreased from 0.87+/-0.02 to 0.83+/-0.02 (P<0.0001) resulting in a 4-day cumulative carbohydrate, fat and protein balances of -183+/-368, 342+/-480 and 65+/-267 kcal, respectively. Cumulative energy balance (224+/-362 kcal per 4 days) did not influence ad libitum energy intake. However, we detected that 4-day carbohydrate balance was a positive and independent predictor of post-chamber ad libitum energy intake (R (2)=0.10; P=0.01), whereas no significant influence of fat and protein balances was found.

CONCLUSION

In response to an isoenergetic change from a high-carbohydrate to HFD, higher carbohydrate balance related to increased energy intake.

摘要

目的

从高碳水化合物饮食（HFD）切换到等能量饮食后，糖原减少可能会促进食物摄入量的代偿性增加，以重新建立碳水化合物平衡。我们评估了从 49%碳水化合物到 50%脂肪的等能量饮食转换对营养平衡和随意进食的影响。我们假设碳水化合物平衡与随意能量摄入呈负相关。

方法

在 47 名男性和 11 名女性（22.6+/-0.4 岁；26.1+/-0.5 kg m(-2)）中，通过呼吸室在 4 天内测量燃料平衡。在第一天，提供等能量、高碳水化合物饮食，然后进行 3 天的等能量、HFD。在此期间结束后，禁食 16 小时后，随意提供三种食物（饼干、水果沙拉和火鸡三明治）供 4 小时食用。研究了呼吸室停留期间和 4 天内测量的餐后随意摄入量与宏量营养素氧化和平衡之间的关系。

结果

切换到 HFD 后，24 小时呼吸商从 0.87+/-0.02 降至 0.83+/-0.02（P<0.0001），导致 4 天累积碳水化合物、脂肪和蛋白质的平衡分别为-183+/-368、342+/-480 和 65+/-267 千卡。4 天的能量平衡（每天 362 千卡）不会影响随意能量摄入。然而，我们发现 4 天的碳水化合物平衡是餐后呼吸室随意能量摄入的正相关和独立预测因子（R (2)=0.10；P=0.01），而脂肪和蛋白质平衡则没有显著影响。