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When less is more: Gaining power through gene rearrangement of amplified .

作者信息

Koga Tomoyuki, Chen Clark C, Furnari Frank B

机构信息

Ludwig Cancer Research, University of California San Diego, La Jolla, CA, USA.

出版信息

Oncotarget. 2019 Mar 15;10(22):2116-2117. doi: 10.18632/oncotarget.26786.

DOI:10.18632/oncotarget.26786
PMID:31040904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6481334/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/6481334/289610c122ab/oncotarget-10-2116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/6481334/289610c122ab/oncotarget-10-2116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac79/6481334/289610c122ab/oncotarget-10-2116-g001.jpg

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本文引用的文献

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Neuro Oncol. 2018 Sep 3;20(10):1310-1320. doi: 10.1093/neuonc/noy058.
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Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.胶质母细胞瘤细胞间的串扰集中在 NF-κB 上,以降低 EGFR 抑制剂的敏感性。
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染色体外致癌基因扩增驱动肿瘤进化和基因异质性。
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Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements.染色体重组与癌症:局部、复杂染色体重排的机制和后果。
Nat Med. 2012 Nov;18(11):1630-8. doi: 10.1038/nm.2988. Epub 2012 Nov 7.
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Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.差异基因表达分析揭示了胶质瘤细胞中一种突变的表皮生长因子受体产生自分泌环的现象。
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Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA.通过微核选择性捕获无着丝粒片段为纯化染色体外扩增DNA提供了一种快速方法。
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